prikaz prve stranice dokumenta Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome
  Download
PDF 116.46 KB
Scientific paper - Original scientific paper
Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome
Croatian Medical Journal, 57 (2016), 6; 558-565. https://doi.org/10.3325/cmj.2016.57.558
Krbot Skorić, Magdalena; Adamec, Ivan; Crnošija, Luka; Gabelić, Tereza; Barun, Barbara; Zadro, Ivana; Butković Soldo, Silva; Habek, Mario

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Krbot Skorić, M., Adamec, I., Crnošija, L., Gabelić, T., Barun, B., Zadro, I. ... Habek, M. (2016). Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome. Croatian Medical Journal, 57. (6), 558-565. doi: 10.3325/cmj.2016.57.558

Krbot Skorić, Magdalena, et al. "Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome." Croatian Medical Journal, vol. 57, no. 6, 2016, pp. 558-565. https://doi.org/10.3325/cmj.2016.57.558

Krbot Skorić, Magdalena, Ivan Adamec, Luka Crnošija, Tereza Gabelić, Barbara Barun, Ivana Zadro, Silva Butković Soldo and Mario Habek. "Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome." Croatian Medical Journal 57, no. 6 (2016): 558-565. https://doi.org/10.3325/cmj.2016.57.558

Krbot Skorić, M., et al. (2016) 'Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome', Croatian Medical Journal, 57(6), pp. 558-565. doi: 10.3325/cmj.2016.57.558

Krbot Skorić M, Adamec I, Crnošija L, Gabelić T, Barun B, Zadro I, and sur.. Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome. Croatian Medical Journal [Internet]. 2016 December [cited 2024 November 26];57(6):558-565. doi: 10.3325/cmj.2016.57.558

M. Krbot Skorić, et al., "Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome", Croatian Medical Journal, vol. 57, no. 6, pp. 558-565, December 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:296896. [Accessed: 26 November 2024]

Metadata
Title (english)Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome
AuthorMagdalena Krbot Skorić
AuthorIvan Adamec
AuthorLuka Crnošija
AuthorTereza Gabelić
AuthorBarbara Barun
AuthorIvana Zadro
AuthorSilva Butković Soldo
AuthorMario Habek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP results in the form of the tSSEP score enables better evaluation of the afferent trigeminal pathway involvement than analyzing each tSSEP parameter separately. ----- METHODS: 115 consecutive CIS patients were enrolled from August 1, 2014 until March 1, 2016. Facial sensory symptoms and brainstem MRI (1.5 T) lesions were analyzed. tSSEP testing was performed for each patient from the raw tSSEP data. The tSSEP score was calculated separately for the left and right side (according to the cut-off values for absent response and prolonged latency of the main component, P1 (0=normal response, 1=prolonged latency, 3=absent response) and the two values were summed. ----- RESULTS: There was no difference in the absolute values of the tSSEP variables regarding the presence of clinical symptoms. No association was found between tSSEP abnormalities and clinical symptoms (P=0.544). Brainstem lesions (midbrain and pons) were associated with the absent tSSEP responses (P=0.002 and P=0.005, respectively). tSSEP score was significantly higher in patients with brainstem lesions (P=0.01), especially midbrain (P=0.004) and pontine (P=0.008) lesions. Binary logistic regression showed that tSSEP score had a significant effect on the likelihood that patients have midbrain MR lesions, ?2(1)=6.804, P=0.009; and the model correctly classified 87% of cases. ----- CONCLUSIONS: The consistent finding of this study was the association between tSSEP and midbrain lesions on MRI, indicating that tSSEP evaluates proprioception of the face. This study establishes the value of tSSEP in assessing brainstem function in early multiple sclerosis.
Abstract (croatian)
Somatosenzorni evocirani potencijali jezika održavaju zahvaćenost srednjeg mozga kod pacijenata s klinički izoliranim sindromom ----- Cilj: Kako bismo testirali hipotezu da somatosenzorni evocirani potencijali jezika (prema engl, tongue somatosensory evoked potentials, tSSEP) odražavaju kliničke lezije i lezije vidljive magnetskom rezonancijom kod pacijenata s multiplom sklerozom, cilj ovog istraživanja bio je utvrditi promjene tSSEP-a kod pacijenata s klinički izoliranim sindromom u odnosu na kliničke nalaze i nalaze moždanog debla dobivene magnetskom rezonancijom. Drugi cilj bio je istražiti omogućuje li interpretacija tSSEP rezultata u obliku tSSEP izračuna bolju procjenu zahvaćenosti aferentnog trigeminalnog puta nego analiza svakog tSSEP parametra posebno. ----- Postupci: U razdoblju od 1. kolovoza 2014. do 1. ožujka 2016. godine u ispitivanje smo uključili 115 uzastopnih pacijenata s klinički izoliranim sindromom. Analizirali smo facijalne senzorne simptome i lezije moždanog debla vidljive magnetskom rezonancijom (1.5 T). tSSEP je izračunat za svakog ispitanika iz neobrađenih podataka, posebno za lijevu i desnu stranu (prema graničnim vrijednostima za odsutni odgovor i produženu latenciju glavne komponente, P1 [0=normalan odgovor, 1=produžena latencija, 3=odsutan odgovor]), te su te dvije vrijednosti zbrojene. ----- Rezultati: Nije bilo razlika u apsolutnim vrijednostima tSSEP varijabli prema prisutnosti kliničkih simptoma. Nije bilo povezanosti između abnormalnosti tSSEP-a i kliničkih simptoma (P=0,544). Lezije moždanog debla (srednji mozak i moždani most) bile su povezane s odsutnim tSSEP odgovorima (P =0,002 odnosno P =0,005). tSSEP izračun bio je značajno viši kod pacijenata s lezijama moždanog debla (P =0,01), posebice lezijama srednjeg mozga (P =0,004) i moždanog mosta (P =0,008). Binarna logistička regresija pokazala je da je tSSEP izračun imao značajan učinak na vjerojatnost da će pacijenti imati leziju u srednjem mozgu, χ2 (1)=6,804, P=0,009; a model je točno razvrstao 87% pacijenata. ----- Zaključak: Ovo ispitivanje opetovano je pokazalo povezanost između tSSEP-a i lezija u srednjem mozgu, ukazujući na to da tSSEP može služiti u procjeni propriocepcije lica. Potvrdili smo ulogu tSSEP-a u ocjeni funkcije moždanog debla u ranom stadiju multiple skleroze.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 57, no. 6, pp. 558-565
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2016.57.558
URN:NBNurn:nbn:hr:105:296896
Publication2016-12
Document URLhttps://doi.org/10.3325/cmj.2016.57.558
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:45:55