prikaz prve stranice dokumenta Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study
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Scientific paper - Review paper
Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study
Journal of Translational Medicine, 14 (2016); 250. https://doi.org/10.1186/s12967-016-1006-6
Pikija, Slaven; Trkulja, Vladimir; Mutzenbach, Johannes Sebastian; McCoy, Mark R.; Ganger, Patricia; Sellner, Johann

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Pikija, S., Trkulja, V., Mutzenbach, J. S., McCoy, M. R., Ganger, P. & Sellner, J. (2016). Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study. Journal of Translational Medicine, 14., 250. doi: 10.1186/s12967-016-1006-6

Pikija, Slaven, et al. "Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study." Journal of Translational Medicine, vol. 14, 2016, p. 250. https://doi.org/10.1186/s12967-016-1006-6

Pikija, Slaven, Vladimir Trkulja, Johannes Sebastian Mutzenbach, Mark R. McCoy, Patricia Ganger and Johann Sellner. "Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study." Journal of Translational Medicine 14 (2016): 250. https://doi.org/10.1186/s12967-016-1006-6

Pikija, S., et al. (2016) 'Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study', Journal of Translational Medicine, 14, p. 250. doi: 10.1186/s12967-016-1006-6

Pikija S, Trkulja V, Mutzenbach JS, McCoy MR, Ganger P, Sellner J. Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study. Journal of Translational Medicine [Internet]. 2016 August 30 [cited 2024 May 03];14:250. doi: 10.1186/s12967-016-1006-6

S. Pikija, V. Trkulja, J. S. Mutzenbach, M. R. McCoy, P. Ganger and J. Sellner, "Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study", Journal of Translational Medicine, vol. 14, p. 250, August 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:378241. [Accessed: 03 May 2024]

Metadata
Title (english)Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study
AuthorSlaven Pikija
AuthorVladimir Trkulja
AuthorJohannes Sebastian Mutzenbach
AuthorMark R. McCoy
AuthorPatricia Ganger
AuthorJohann Sellner
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of soluble fibrinogen to an insoluble fibrin network. Quantitative features of intracranial clots causing acute ischemic stroke can be studied on non-contrast enhanced CT (NECT). Here, we evaluated on-admission fibrinogen and clot burden in relation to stroke severity, final infarct volume and in-hospital mortality. ----- METHODS: We included 132 consecutive patients with ischemic stroke and presence of hyperdense artery sign admitted within 6 h from symptom onset. Radiological parameters including clot area (corresponding to clot burden) and final infarct volume were manually determined on NECT. National Institute of Health Stroke Scale (NIHSS) was used to quantify disease severity and short-term outcome. ----- RESULTS: Median patient age was 77, 58 % were women, and 63 % had an occlusion of the proximal middle cerebral artery segment. Thrombolysis was performed in 60 % and thrombectomy in 44 %. We identified several independent associations. Higher fibrinogen levels on admission were associated with smaller clot burden (p = 0.033) and lower NIHSS on admission (p = 0.022). Patients with lower fibrinogen had a higher clot burden (p = 0.028) and greater final infarct volume (p = 0.003). Higher fibrinogen was associated with a lower risk of in-hospital death or NIHSS score >15 if discharged alive (p = 0.028). ----- CONCLUSIONS: Our study suggests that intracranial clot burden in acute ischemic stroke is associated with fibrinogen consumption, and shows a complex relationship with disease severity, infarct size and in-hospital survival.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Translational Medicine
Numberingvol. 14, p. 250
p-ISSN1479-5876
DOIhttps://doi.org/10.1186/s12967-016-1006-6
URN:NBNurn:nbn:hr:105:378241
Publication2016-08-30
Document URLhttps://doi.org/10.1186/s12967-016-1006-6
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:49:22