prikaz prve stranice dokumenta Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis
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Scientific paper - Original scientific paper
Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis
Clinical Neurophysiology, 127 (2016), 1; 864-869. https://doi.org/10.1016/j.clinph.2015.06.010
Crnošija, Luka; Adamec, Ivan; Lovrić, Mila; Junaković, Anamari; Krbot Skorić, Magdalena; Lušić, Ivo; Habek, Mario

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Crnošija, L., Adamec, I., Lovrić, M., Junaković, A., Krbot Skorić, M., Lušić, I. & Habek, M. (2016). Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis. Clinical Neurophysiology, 127. (1), 864-869. doi: 10.1016/j.clinph.2015.06.010

Crnošija, Luka, et al. "Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis." Clinical Neurophysiology, vol. 127, no. 1, 2016, pp. 864-869. https://doi.org/10.1016/j.clinph.2015.06.010

Crnošija, Luka, Ivan Adamec, Mila Lovrić, Anamari Junaković, Magdalena Krbot Skorić, Ivo Lušić and Mario Habek. "Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis." Clinical Neurophysiology 127, no. 1 (2016): 864-869. https://doi.org/10.1016/j.clinph.2015.06.010

Crnošija, L., et al. (2016) 'Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis', Clinical Neurophysiology, 127(1), pp. 864-869. doi: 10.1016/j.clinph.2015.06.010

Crnošija L, Adamec I, Lovrić M, Junaković A, Krbot Skorić M, Lušić I, and sur.. Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis. Clinical Neurophysiology [Internet]. 2016 January [cited 2024 December 23];127(1):864-869. doi: 10.1016/j.clinph.2015.06.010

L. Crnošija, et al., "Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis", Clinical Neurophysiology, vol. 127, no. 1, pp. 864-869, January 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:626285. [Accessed: 23 December 2024]

Metadata
Title (english)Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis
AuthorLuka Crnošija
AuthorIvan Adamec
AuthorMila Lovrić
AuthorAnamari Junaković
AuthorMagdalena Krbot Skorić
AuthorIvo Lušić
AuthorMario Habek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: The aim of this study was to determine the extent of autonomic dysfunction in patients with clinically isolated syndrome (CIS) by using a standardized battery of autonomic tests in the form of the Composite Autonomic Scoring Scale (CASS). ----- METHODS: This was a prospective, cross sectional study which included 24 consecutive patients who were diagnosed with CIS and 17 healthy controls. In all participants, heart rate and blood pressure responses to the Valsalva maneuver, heart rate response to deep breathing and blood pressure response to passive tilt were performed. In 16 patients, Quantitative Sudomotor Axon Reflex Test (QSART) and catecholamine measurement was performed. ----- RESULTS: The proportion of CIS patients with pathological adrenergic index was statistically significantly higher compared to healthy controls (12 vs 2, p=0.018), while there was no difference in cardiovagal index between groups. Five patients had a sudomotor index of 1 (in 4 there was hypohydrosis <50% and in 1 persistent foot hyperhidrosis). When combining adrenergic, cardiovagal and sudomotor index into CASS, 8 patients (50%) had evidence of autonomic dysfunction, 7 mild and one moderate. ----- CONCLUSION: Sympathetic nervous system is frequently affected in CIS patients. ----- SIGNIFICANCE: CASS is able to detect autonomic nervous system dysfunction in CIS patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleClinical Neurophysiology
Numberingvol. 127, no. 1, pp. 864-869
p-ISSN1388-2457
DOIhttps://doi.org/10.1016/j.clinph.2015.06.010
URN:NBNurn:nbn:hr:105:626285
Publication2016-01
Document URLhttps://doi.org/10.1016/j.clinph.2015.06.010
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:54:32