prikaz prve stranice dokumenta The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation
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Scientific paper - Original scientific paper
The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation
International Journal of Hematology, 102 (2015), 1; 12-24. https://doi.org/10.1007/s12185-015-1776-2
Dembitz, Vilma; Lalić, Hrvoje; Ostojić, Alen; Vrhovac, Radovan; Banfić, Hrvoje; Višnjić, Dora

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Dembitz, V., Lalić, H., Ostojić, A., Vrhovac, R., Banfić, H. & Višnjić, D. (2015). The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. International Journal of Hematology, 102. (1), 12-24. doi: 10.1007/s12185-015-1776-2

Dembitz, Vilma, et al. "The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation." International Journal of Hematology, vol. 102, no. 1, 2015, pp. 12-24. https://doi.org/10.1007/s12185-015-1776-2

Dembitz, Vilma, Hrvoje Lalić, Alen Ostojić, Radovan Vrhovac, Hrvoje Banfić and Dora Višnjić. "The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation." International Journal of Hematology 102, no. 1 (2015): 12-24. https://doi.org/10.1007/s12185-015-1776-2

Dembitz, V., et al. (2015) 'The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation', International Journal of Hematology, 102(1), pp. 12-24. doi: 10.1007/s12185-015-1776-2

Dembitz V, Lalić H, Ostojić A, Vrhovac R, Banfić H, Višnjić D. The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. International Journal of Hematology [Internet]. 2015 July [cited 2024 April 29];102(1):12-24. doi: 10.1007/s12185-015-1776-2

V. Dembitz, H. Lalić, A. Ostojić, R. Vrhovac, H. Banfić and D. Višnjić, "The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation", International Journal of Hematology, vol. 102, no. 1, pp. 12-24, July 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:118218. [Accessed: 29 April 2024]

Metadata
Title (english)The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation
AuthorVilma Dembitz
AuthorHrvoje Lalić
AuthorAlen Ostojić
AuthorRadovan Vrhovac
AuthorHrvoje Banfić
AuthorDora Višnjić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Arsenic trioxide (ATO) has potent clinical activity in the treatment of patients with acute promyelocytic leukemia (APL), but is much less efficacious in acute myeloid leukemia (AML) lacking t(15;17) translocation. Recent studies have indicated that the addition of mammalian target of rapamycin (mTOR) inhibitors may increase the sensitivity of malignant cells to ATO. The aim of the present study was to test for possible synergistic effects of ATO and rapamycin at therapeutically achievable doses in non-APL AML cells. In HL-60 and U937 cell lines, the inhibitory effects of low concentrations of ATO and rapamycin were synergistic and more pronounced in U937 cells. The combination of drugs increased apoptosis in HL-60 cells and increased the percentage of cells in G(0)/G(1) phase in both cell lines. In U937 cells, rapamycin alone increased the activity of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and the addition of ATO decreased the level of phosphorylated ERK, Ser473 phosphorylated Akt and anti-apoptotic Mcl-1 protein. Primary AML cells show high sensitivity to growth-inhibitory effects of rapamycin alone or in combination with ATO. The results of the present study reveal the mechanism of the synergistic effects of two drugs at therapeutically achievable doses in non-APL AML cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Journal of Hematology
Numberingvol. 102, no. 1, pp. 12-24
p-ISSN0925-5710
DOIhttps://doi.org/10.1007/s12185-015-1776-2
URN:NBNurn:nbn:hr:105:118218
Publication2015-07
Document URLhttps://doi.org/10.1007/s12185-015-1776-2
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:54:53