prikaz prve stranice dokumenta The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection
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Scientific paper - Original scientific paper
The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection
Microbial Pathogenesis, 97 (2016); 125-30. https://doi.org/10.1016/j.micpath.2016.06.008
Gorenec, Lana; Židovec Lepej, Snježana; Grgić, Ivana; Planinić, Ana; Iščić Beš, Janja; Vince, Adriana; Begovac, Josip

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Gorenec, L., Židovec Lepej, S., Grgić, I., Planinić, A., Iščić Beš, J., Vince, A. & Begovac, J. (2016). The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection. Microbial Pathogenesis, 97., 125-30. doi: 10.1016/j.micpath.2016.06.008

Gorenec, Lana, et al. "The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection." Microbial Pathogenesis, vol. 97, 2016, pp. 125-30. https://doi.org/10.1016/j.micpath.2016.06.008

Gorenec, Lana, Snježana Židovec Lepej, Ivana Grgić, Ana Planinić, Janja Iščić Beš, Adriana Vince and Josip Begovac. "The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection." Microbial Pathogenesis 97 (2016): 125-30. https://doi.org/10.1016/j.micpath.2016.06.008

Gorenec, L., et al. (2016) 'The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection', Microbial Pathogenesis, 97, pp. 125-30. doi: 10.1016/j.micpath.2016.06.008

Gorenec L, Židovec Lepej S, Grgić I, Planinić A, Iščić Beš J, Vince A, and sur.. The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection. Microbial Pathogenesis [Internet]. 2016 August [cited 2024 November 26];97:125-30. doi: 10.1016/j.micpath.2016.06.008

L. Gorenec, et al., "The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection", Microbial Pathogenesis, vol. 97, pp. 125-30, August 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:186418. [Accessed: 26 November 2024]

Metadata
Title (english)The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection
AuthorLana Gorenec
AuthorSnježana Židovec Lepej
AuthorIvana Grgić
AuthorAna Planinić
AuthorJanja Iščić Beš
AuthorAdriana Vince
AuthorJosip Begovac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of this study was to compare cytokine expression on both gene and protein levels in acute and chronic phase of HIV type 1 (HIV-1) infection. Thirty four patients were enrolled for cytokine expression analysis on protein level in acute and chronic stage of HIV-1 infection. Using PCR array technology, expression of 84 cytokine genes was measured in 3 patients in acute and 3 patients in chronic stage of HIV-1 infection. Bead-based cytometry was used to quantify levels of Th1/Th2/Th9/Th17/Th22 cytokines. The results showed statistically significant increase of 13 cytokine gene expression (cd40lg, csf2, ifna5, il12b, il1b, il20, lta, osm, spp1, tgfa, tnfsf 11, 14 and 8) and downregulation of the il12a expression in chronic HIV type 1 infection. Concentrations of IL-10, IL-4 and TNF-α were increased in the acute HIV type 1 infection when compared to control group. During chronic HIV type 1 infection there was an increase of IL-10, TNF-α, IL-2, IL-6, IL-13 and IL-22 levels when compared to control group. Comparison of cytokine expression between two stages of infection showed a significant decrease in IL-9 concentration. This study showed changes in cytokine profiles on both gene and protein levels in different stages of HIV-infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMicrobial Pathogenesis
Numberingvol. 97, pp. 125-30
p-ISSN0882-4010
DOIhttps://doi.org/10.1016/j.micpath.2016.06.008
URN:NBNurn:nbn:hr:105:186418
Publication2016-08
Document URLhttp://doi.org/10.1016/j.micpath.2016.06.008
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:56:19