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Scientific paper - Review paper
Botulinum toxin type A in motor nervous system: unexplained observations and new challenges
Journal of Neural Transmission, 123 (2016), 12; 1415-1421. https://doi.org/10.1007/s00702-016-1611-9
Matak, Ivica; Lacković, Zdravko; Relja, Maja

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Matak, I., Lacković, Z. & Relja, M. (2016). Botulinum toxin type A in motor nervous system: unexplained observations and new challenges. Journal of Neural Transmission, 123. (12), 1415-1421. doi: 10.1007/s00702-016-1611-9

Matak, Ivica, et al. "Botulinum toxin type A in motor nervous system: unexplained observations and new challenges." Journal of Neural Transmission, vol. 123, no. 12, 2016, pp. 1415-1421. https://doi.org/10.1007/s00702-016-1611-9

Matak, Ivica, Zdravko Lacković and Maja Relja. "Botulinum toxin type A in motor nervous system: unexplained observations and new challenges." Journal of Neural Transmission 123, no. 12 (2016): 1415-1421. https://doi.org/10.1007/s00702-016-1611-9

Matak, I., Lacković, Z. and Relja, M. (2016) 'Botulinum toxin type A in motor nervous system: unexplained observations and new challenges', Journal of Neural Transmission, 123(12), pp. 1415-1421. doi: 10.1007/s00702-016-1611-9

Matak I, Lacković Z, Relja M. Botulinum toxin type A in motor nervous system: unexplained observations and new challenges. Journal of Neural Transmission [Internet]. 2016 December [cited 2024 May 04];123(12):1415-1421. doi: 10.1007/s00702-016-1611-9

I. Matak, Z. Lacković and M. Relja, "Botulinum toxin type A in motor nervous system: unexplained observations and new challenges", Journal of Neural Transmission, vol. 123, no. 12, pp. 1415-1421, December 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:728800. [Accessed: 04 May 2024]

Metadata
Title (english)Botulinum toxin type A in motor nervous system: unexplained observations and new challenges
AuthorIvica Matak
AuthorZdravko Lacković
AuthorMaja Relja
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
In the motor system, botulinum toxin type A (BoNT/A) actions were classically attributed to its well-known peripheral anticholinergic actions in neuromuscular junctions. However, the enzymatic activity of BoNT/A, assessed by the detection of cleaved synaptosomal-associated protein 25 (SNAP-25), was recently detected in motor and sensory regions of the brainstem and spinal cord after toxin peripheral injection in rodents. In sensory regions, the function of BoNT/A activity is associated with its antinociceptive effects, while in motor regions we only know that BoNT/A activity is present. Is it possible that BoNT/A presence in central motor nuclei is without any function? In this brief review, we analyze this question. Limited data available in the literature warrant further investigations of BoNT/A actions in motor nervous system.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neural Transmission
Numberingvol. 123, no. 12, pp. 1415-1421
p-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-016-1611-9
URN:NBNurn:nbn:hr:105:728800
Publication2016-12
Document URLhttp://doi.org/10.1007/s00702-016-1611-9
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:58:44