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master's thesis
Patohistološki pristup transplantacije jetre
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:384857
Margeta, Ivan
University of Zagreb
School of Medicine
Department of Pathology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Margeta, I. (2015). Patohistološki pristup transplantacije jetre (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:384857

Margeta, Ivan. "Patohistološki pristup transplantacije jetre." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:384857

Margeta, Ivan. "Patohistološki pristup transplantacije jetre." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:384857

Margeta, I. (2015). 'Patohistološki pristup transplantacije jetre', Master's thesis, University of Zagreb, School of Medicine, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:384857

Margeta I. Patohistološki pristup transplantacije jetre [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:384857

I. Margeta, "Patohistološki pristup transplantacije jetre", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:384857

Metadata
TitlePatohistološki pristup transplantacije jetre
Title (english)Pathohistological approach to liver transplantation
AuthorIvan Margeta
MentorSlavko Gašparov (mentor)
Committee memberMarijana Ćorić (predsjednik povjerenstva)
Committee memberAnita Škrtić (član povjerenstva)
Committee memberSlavko Gašparov (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pathology)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Jetra je vitalni organ čovjeka. Ima važnu ulogu u metabolizmu hranjivih tvari i lijekova, sintezi proteina i filtraciji krvi. Zbog svoje složene građe i mnogobrojnih funkcija jetra je često sijelo bolesti. Postoje mnogobrojna patološka stanja jetre, no u kontekstu transplantacijske patologije najbitnija su ona koja dovode do akutnog zatajenja jetre, kroničnog zatajenja jetre i ciroze. Ove bolesti liječe se transplantacijom jetre. Transplantacijska patologija bavi se bolestima koje se pojavljuju na alotransplantatu: prezervacijsko oštećenje, vaskularne komplikacije, komplikacije žučnih vodova, odbacivanje organa, infekcije i recidivirajuće bolesti. Prezervacijsko oštećenje nastaje kao posljedica produljenog vremena tople i hladne ishemije. Vaskularne komplikacije i komplikacije žučnih vodova najčešće su posljedica kirurških komplikacija. Infekcije hepatitis B virusom i hepatitis C virusom često recidiviraju i progresivno vode do zatajenja alotransplantata. Odbacivanje organa dijeli se na humoralno, akutno i kronično. Recidivirajuće bolesti uključuju infektivne, imunološke, tumorske i toksične bolesti jetre. Glavna dijagnostička metoda većine ovih stanja je biopsija jetre i patohistološki pregled tkiva. Međutim mikroskopska slika ovih bolesti često je nespecifična i vrlo isprepletena. Neke bolesti posebno je teško razlikovati samo na temelju mikroskopske slike. Zbog toga je potrebno poznavati vrijeme proteklo od transplantacije, kliničku sliku bolesti i stanje pacijenta te široku diferencijalnu dijagnozu koja dolazi u obzir.
Abstract (english)
The liver is a vital human organ. It has an important role in nutrient and drug metabolism, protein synthesis and blood filtration. Because of its complex structure and multiple functions the liver is a common site of diseases. There are lots of possible pathological states of the liver, but in the context of liver transplantation pathology the most important are: acute liver failure, chronic liver failure and cirrhosis. These diseases are treated with liver transplantation. Transplantation pathology covers diseases that occur on the allograft: preservation injury, vascular complications, bile duct complications, rejection, infections and reccurent diseases. Preservation injury occurs due to prolonged cold and hot ischemia. Vascular complications and bile duct complications are usually a result of surgical complications. Hepatitis B and hepatitis C infections commonly recur in the allograft and lead to progressive allograft failure. Liver rejection is divided into humoral, acute and chronic. Recurrent diseases include infective, immune, neoplastic and toxic liver diseases. The main diagnostic method for most of these diseases is liver biopsy and pathohistological tissue examination. However the microscopic findings can be unspecific and overlapping. Some diseases can be difficult to distinguish based on microscopic findings alone. Therefore it is important to know the time after transplantation, the clinical presentation of the disease and the broad differential diagnosis that needs to be considered
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:384857
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-08-09 10:19:20