prikaz prve stranice dokumenta Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior
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Scientific paper - Original scientific paper
Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 63 (2015); 119-125. https://doi.org/10.1016/j.pnpbp.2015.06.010
Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Nenadić Šviglin, Korona; Borovečki, Fran; Pivac, Nela

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Švob Štrac, D., Nedić Erjavec, G., Nikolac Perković, M., Nenadić Šviglin, K., Borovečki, F. & Pivac, N. (2015). Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 63., 119-125. doi: 10.1016/j.pnpbp.2015.06.010

Švob Štrac, Dubravka, et al. "Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior." Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 63, 2015, pp. 119-125. https://doi.org/10.1016/j.pnpbp.2015.06.010

Švob Štrac, Dubravka, Gordana Nedić Erjavec, Matea Nikolac Perković, Korona Nenadić Šviglin, Fran Borovečki and Nela Pivac. "Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior." Progress in Neuro-Psychopharmacology & Biological Psychiatry 63 (2015): 119-125. https://doi.org/10.1016/j.pnpbp.2015.06.010

Švob Štrac, D., et al. (2015) 'Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 63, pp. 119-125. doi: 10.1016/j.pnpbp.2015.06.010

Švob Štrac D, Nedić Erjavec G, Nikolac Perković M, Nenadić Šviglin K, Borovečki F, Pivac N. Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. Progress in Neuro-Psychopharmacology & Biological Psychiatry [Internet]. 2015 December 03 [cited 2024 November 08];63:119-125. doi: 10.1016/j.pnpbp.2015.06.010

D. Švob Štrac, G. Nedić Erjavec, M. Nikolac Perković, K. Nenadić Šviglin, F. Borovečki and N. Pivac, "Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior", Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 63, pp. 119-125, December 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:547575. [Accessed: 08 November 2024]

Metadata
Title (english)Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior
AuthorDubravka Švob Štrac
AuthorGordana Nedić Erjavec
AuthorMatea Nikolac Perković
AuthorKorona Nenadić Šviglin
AuthorFran Borovečki
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Alcohol dependence is a common chronic disorder precipitated by the complex interaction between biological, genetic and environmental risk factors. Recent studies have demonstrated that polymorphisms of the gene encoding the GABAA receptor α2 subunit (GABRA2) are associated with alcohol dependence in different populations of European ancestry. As aggression often occurs in the context of alcohol dependence, the aim of this study was to examine the allelic and haplotypic association of GABRA2 gene with alcohol dependence and related aggressive behavior in subjects of Eastern European (Croatian) origin. Genotyping of the 3 single nucleotide polymorphisms (SNPs) across the GABRA2 gene (rs567926, rs279858 and rs9291283) was performed in patients with alcohol dependence (N=654) and healthy control subjects (N=574). Alcohol-dependent participants were additionally subdivided according to the presence/absence of aggressive behavior and type of alcohol dependence according to the Cloninger's classification. The association of rs279858 with alcohol dependence yielded nominal significance level. Haplotype analysis revealed a high degree of linkage disequilibrium (LD) for rs567926 and rs279858, but not for rs9291283 polymorphism in the GABRA2 gene. In patients with alcohol dependence, the A-C (rs567926 and rs279858) haplotype carriers were more likely to demonstrate aggressive behavior. The same haplotype (present only in 1.6% of all subjects) was significantly more often present in patients with a combination of early onset alcohol abuse and aggression, corresponding to the Cloninger's type II alcoholism subgroup. These findings support the involvement of GABRA2 gene in alcohol dependence-related aggressive behavior.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProgress in Neuro-Psychopharmacology & Biological Psychiatry
Numberingvol. 63, pp. 119-125
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2015.06.010
URN:NBNurn:nbn:hr:105:547575
Publication2015-12-03
Document URLhttps://doi.org/10.1016/j.pnpbp.2015.06.010
Type of resourceText
Access conditionsOpen access
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Created on2024-03-28 09:02:51