prikaz prve stranice dokumenta IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis
  Download
PDF 455.14 KB
Scientific paper - Original scientific paper
IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis
Croatian Medical Journal, 58 (2017), 4; 281-291. https://doi.org/10.3325/cmj.2017.58.281
Pačić, Arijana; Šenjug, Petar; Bacalja, Jasna; Tišljar, Miroslav; Horvatić, Ivica; Bulimbašić, Stela; Knotek, Mladen; Galešić, Krešimir; Galešić Ljubanović, Danica

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Pačić, A., Šenjug, P., Bacalja, J., Tišljar, M., Horvatić, I., Bulimbašić, S. ... Galešić Ljubanović, D. (2017). IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis. Croatian Medical Journal, 58. (4), 281-291. doi: 10.3325/cmj.2017.58.281

Pačić, Arijana, et al. "IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis." Croatian Medical Journal, vol. 58, no. 4, 2017, pp. 281-291. https://doi.org/10.3325/cmj.2017.58.281

Pačić, Arijana, Petar Šenjug, Jasna Bacalja, Miroslav Tišljar, Ivica Horvatić, Stela Bulimbašić, Mladen Knotek, Krešimir Galešić and Danica Galešić Ljubanović. "IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis." Croatian Medical Journal 58, no. 4 (2017): 281-291. https://doi.org/10.3325/cmj.2017.58.281

Pačić, A., et al. (2017) 'IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis', Croatian Medical Journal, 58(4), pp. 281-291. doi: 10.3325/cmj.2017.58.281

Pačić A, Šenjug P, Bacalja J, Tišljar M, Horvatić I, Bulimbašić S, and sur.. IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis. Croatian Medical Journal [Internet]. 2017 August 31 [cited 2024 November 08];58(4):281-291. doi: 10.3325/cmj.2017.58.281

A. Pačić, et al., "IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis", Croatian Medical Journal, vol. 58, no. 4, pp. 281-291, August 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:114917. [Accessed: 08 November 2024]

Metadata
Title (english)IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis
AuthorArijana Pačić
AuthorPetar Šenjug
AuthorJasna Bacalja
AuthorMiroslav Tišljar
AuthorIvica Horvatić
AuthorStela Bulimbašić
AuthorMladen Knotek
AuthorKrešimir Galešić
AuthorDanica Galešić Ljubanović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS). ----- METHODS: Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outcome data were obtained and compared to morphological parameters, including immunofluorescence analysis of mesangial IgM and complement 3 (C3) deposits analyzed on kidney biopsy samples. ----- RESULTS: There were significant positive correlations between IgM and C3 deposition in secondary FSGS (P<0.001) and between IgM and mesangial deposits detected by electron microscopy in secondary FSGS (P=0.015), which indicated that higher IgM deposition correlated with higher C3 deposition and mesangial deposits only in secondary FSGS. Patients with secondary FSGS and the deposition of IgM showed inferior renal outcomes at earlier time points in comparison with patients with negative IgM expression (P=0.022). ----- CONCLUSIONS: We detected a positive correlation between IgM and C3 in secondary FSGS. The association between IgM deposition and worse renal outcome in secondary FSGS indicates that IgM may play a role in the progression of this disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 58, no. 4, pp. 281-291
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2017.58.281
URN:NBNurn:nbn:hr:105:114917
Publication2017-08-31
Document URLhttps://doi.org/10.3325/cmj.2017.58.281
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:10:17