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master's thesis
Liječenje neuroendokrinih tumora
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:639606
Turudić, Ana
University of Zagreb
School of Medicine
Department of Pathophysiology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Turudić, A. (2015). Liječenje neuroendokrinih tumora (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:639606

Turudić, Ana. "Liječenje neuroendokrinih tumora." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:639606

Turudić, Ana. "Liječenje neuroendokrinih tumora." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:639606

Turudić, A. (2015). 'Liječenje neuroendokrinih tumora', Master's thesis, University of Zagreb, School of Medicine, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:639606

Turudić A. Liječenje neuroendokrinih tumora [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:639606

A. Turudić, "Liječenje neuroendokrinih tumora", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:639606

Metadata
TitleLiječenje neuroendokrinih tumora
Title (english)Treatment of neuroendocrine tumors
AuthorAna Turudić
MentorBorislav Belev (mentor)
Committee memberDAMIR VRBANEC (predsjednik povjerenstva)
Committee memberNikola Đaković (član povjerenstva)
Committee memberBorislav Belev (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pathophysiology)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Abstract
Neuroendokrini tumori su novotvorine koje potječu iz neuroendokrinih stanica koje su lokalizirane u različitim dijelovima tijela, najčešće u gastrointestinalnom i bronhopulmonalnom sustavu gdje je mreža tih stanica najgušća. Najčešća mjesta metastaziranja su okolni limfni čvorovi, jetra i kosti. Često prekomjerno izlučuju hormone, pa mogu izazvati brojne kliničke simptome te kao takvi predstavljaju poseban dijagnostički i terapijski entitet. Pojavnost neuroendokrinih tumora uglavnom je sporadična, no mogu se razviti i u sklopu multiple endokrine neoplazije tip 1, dok se gastrinomi (2/3) i inzulinomi (1/3) najčešće pojavljuju u hereditarnim sindromima. Neuroendokrine tumore osobitim čine i fiziološke osobine jer stanice NET-a mogu pokazivati fenotipsku sličnost s neuralnim stanicama zbog ekspresije proteina poput sinaptofizina, kromogranina i neuron specifične enolaze. Klinička slika neuroendokrinih tumora može se prezentirati pojavom boli, mučnine, proljeva, spaciokompresivnog sindroma ili se mogu javiti simptomi vezani uz hipersekreciju hormona. Danas se kao važno područje istraživanja nameće pronalaženje ključnih molekularnih mehanizama i genetskih mutacija koji bi razjasnili nastanak i napredovanje neuroendokrinih tumora jer je tumorski rast, kao i odgovor na liječenje, nepredvidljiv. Biološke osobitosti, dulje preživljenje bolesnika i mogućnost praćenja humoralnih biljega čine ih grupom tumora kod kojih je moguće pratiti učinke konzervativnog liječenja.
Abstract (english)
Neuroendocrine tumors are neoplasms that originate from neuroendocrine cells which can be found in different tissues and organs of human body. The greatest concentration of those cell types can be found in gastrointestinal and bronchopulmonal tracts. The most common sites of neuroendocrine tumor metastasis are regional lymph nodes, liver and bone. Some neuroendocrine tumors are functional, which means they produce excess hormones that can lead to a variety of hormone-related symptoms. Most neuroendocrine tumours are mainly sporadic, but association with the multiple endocrine neoplasia type 1 syndrome and clustering within families is known. Gastrinomas and insulinomas are mostly associated with hereditary syndromes. Cells of these neoplasms share common phenotypic characteristics, such as chromogranins, synaptophysin and neuron-specific enolase, with neural cells. The most common clinical presentations include abdominal pain, nausea, diarrhea, compartment syndrome or other hormone-related symptoms. Various further novel strategies of targeted therapy and discovering of molecular mechanisms and genetic mutations which play an important role in tumor growth are under development. Biological characteristics, long-term survival of patients with NETs and available markers makes both diagnosis and therapeutic evaluation possible.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:639606
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-08-09 11:29:40