prikaz prve stranice dokumenta Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation
  Download
PDF 1.42 MB
Scientific paper - Original scientific paper
Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation
Kidney & Blood Pressure Research, 41 (2016), 6; 781-793. https://doi.org/10.1159/000450568
Bašić-Jukić, Nikolina; Gulin, Marijana; Hudolin, Tvrtko; Kaštelan, Željko; Katalinić, Lea; Ćorić, Marijana; Varnai, Veda Marija; Ivković, Vanja; Kes, Petar; Jelaković, Bojan

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Bašić Jukić, N., Gulin, M., Hudolin, T., Kaštelan, Ž., Katalinić, L., Ćorić, M. ... Jelaković, B. (2016). Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation. Kidney & Blood Pressure Research, 41. (6), 781-793. doi: 10.1159/000450568

Bašić Jukić, Nikolina, et al. "Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation." Kidney & Blood Pressure Research, vol. 41, no. 6, 2016, pp. 781-793. https://doi.org/10.1159/000450568

Bašić Jukić, Nikolina, Marijana Gulin, Tvrtko Hudolin, Željko Kaštelan, Lea Katalinić, Marijana Ćorić, Veda Marija Varnai, Vanja Ivković, Petar Kes and Bojan Jelaković. "Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation." Kidney & Blood Pressure Research 41, no. 6 (2016): 781-793. https://doi.org/10.1159/000450568

Bašić Jukić, N., et al. (2016) 'Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation', Kidney & Blood Pressure Research, 41(6), pp. 781-793. doi: 10.1159/000450568

Bašić Jukić N, Gulin M, Hudolin T, Kaštelan Ž, Katalinić L, Ćorić M, and sur.. Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation. Kidney & Blood Pressure Research [Internet]. 2016 [cited 2024 April 28];41(6):781-793. doi: 10.1159/000450568

N. Bašić Jukić, et al., "Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation", Kidney & Blood Pressure Research, vol. 41, no. 6, pp. 781-793, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:296598. [Accessed: 28 April 2024]

Metadata
Title (english)Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation
AuthorNikolina Bašić-Jukić
AuthorMarijana Gulin
AuthorTvrtko Hudolin
AuthorŽeljko Kaštelan
AuthorLea Katalinić
AuthorMarijana Ćorić
AuthorVeda Marija Varnai
AuthorVanja Ivković
AuthorPetar Kes
AuthorBojan Jelaković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND/AIMS: Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF. ----- METHODS: 79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry. ----- RESULTS: Lower intensity of BMP2e staining was recorded in DGF compared to IGF. In DGF patients, 93% had no expression of BMP2e and 7% had 1st grade expression, compared to 45% and 41% in IGF group, respectively (P=0.001) (P<0.001 for no expression and P = 0.015 for 1st grade expression). Patients who had BMP2e staining positive had lower odds for DGF (OR 0.059 [0.007, 0.477]) and this remained significant even after adjustment for donor and recipient variables, cold ischemia time, and immunological matching (OR 0.038 [0.003, 0.492]). ----- CONCLUSIONS: Our results demonstrate that BMP-2 expression in endothelial cells of epigastric arteries may predict development of DGF.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleKidney & Blood Pressure Research
Numberingvol. 41, no. 6, pp. 781-793
p-ISSN1420-4096
DOIhttps://doi.org/10.1159/000450568
URN:NBNurn:nbn:hr:105:296598
Publication2016
Document URLhttps://doi.org/10.1159/000450568
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:14:17