prikaz prve stranice dokumenta Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?
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Scientific paper - Original scientific paper
Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?
Journal of Neural Transmission, 124 (2017), 6; 695-708. https://doi.org/10.1007/s00702-017-1727-6
Knezović, Ana; Lončar, Anamarija; Homolak, Jan; Smailović, Una; Osmanović Barilar, Jelena; Ganoci, Lana; Božina, Nada; Riederer, Peter; Šalković-Petrišić, Melita

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Knezović, A., Lončar, A., Homolak, J., Smailović, U., Osmanović Barilar, J., Ganoci, L. ... Šalković Petrišić, M. (2017). Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?. Journal of Neural Transmission, 124. (6), 695-708. doi: 10.1007/s00702-017-1727-6

Knezović, Ana, et al. "Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?." Journal of Neural Transmission, vol. 124, no. 6, 2017, pp. 695-708. https://doi.org/10.1007/s00702-017-1727-6

Knezović, Ana, Anamarija Lončar, Jan Homolak, Una Smailović, Jelena Osmanović Barilar, Lana Ganoci, Nada Božina, Peter Riederer and Melita Šalković Petrišić. "Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?." Journal of Neural Transmission 124, no. 6 (2017): 695-708. https://doi.org/10.1007/s00702-017-1727-6

Knezović, A., et al. (2017) 'Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?', Journal of Neural Transmission, 124(6), pp. 695-708. doi: 10.1007/s00702-017-1727-6

Knezović A, Lončar A, Homolak J, Smailović U, Osmanović Barilar J, Ganoci L, and sur.. Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?. Journal of Neural Transmission [Internet]. 2017 June [cited 2024 November 22];124(6):695-708. doi: 10.1007/s00702-017-1727-6

A. Knezović, et al., "Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?", Journal of Neural Transmission, vol. 124, no. 6, pp. 695-708, June 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:040541. [Accessed: 22 November 2024]

Metadata
Title (english)Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?
AuthorAna Knezović
AuthorAnamarija Lončar
AuthorJan Homolak
AuthorUna Smailović
AuthorJelena Osmanović Barilar
AuthorLana Ganoci
AuthorNada Božina
AuthorPeter Riederer
AuthorMelita Šalković-Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Accumulated evidence suggests that the insulin-resistant brain state and cerebral glucose hypometabolism might be the cause, rather than the consequence, of the neurodegeneration found in a sporadic Alzheimer's disease (sAD). We have explored whether the insulin receptor (IR) and the glucose transporter-2 (GLUT2), used here as their markers, are the early targets of intracerebroventricularly (icv) administered streptozotocin (STZ) in an STZ-icv rat model of sAD, and whether their changes are associated with the STZ-induced neuroinflammation. The expression of IR, GLUT2 and glial fibrillary acidic protein (GFAP) was measured by immunofluorescence and western blot analysis in the parietal (PC) and the temporal (TC) cortex, in the hippocampus (HPC) and the hypothalamus. One hour after the STZ-icv administration (1.5 mg/kg), the GFAP immunoreactivity was significantly increased in all four regions, thus indicating the wide spread neuroinflammation, pronounced in the PC and the HPC. Changes in the GLUT2 (increment) and the IR (decrement) expression were mild in the areas close to the site of the STZ injection/release but pronounced in the ependymal lining cells of the third ventricle, thus indicating the possible metabolic implications. These results, together with the finding of the GLUT2-IR co-expression, and also the neuronal IR expression in PC, TC and HPC, indicate that the cerebral GLUT2 and IR should be further explored as the possible sAD etiopathogenic factors. It should be further clarified whether their alterations are the effect of a direct STZ-icv toxicity or they are triggered in a response to STZ-icv induced neuroinflammation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neural Transmission
Numberingvol. 124, no. 6, pp. 695-708
p-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-017-1727-6
URN:NBNurn:nbn:hr:105:040541
Publication2017-06
Document URLhttps://doi.org/10.1007/s00702-017-1727-6
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:13:22