prikaz prve stranice dokumenta Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
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Scientific paper - Original scientific paper
Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
Journal of Global Antimicrobial Resistance, 10 (2017); 213-218. https://doi.org/10.1016/j.jgar.2017.07.001
Ladavac, Ranko; Bedenić, Branka; Vranić-Ladavac, Mirna; Barišić, Nada; Karčić, Natalie; Pompe, Karoline; Ferenčić, Antun; Stojanović, Aleksandar; Seifert, Harald; Katić, Stjepan; Higgins, Paul G.

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Ladavac, R., Bedenić, B., Vranić Ladavac, M., Barišić, N., Karčić, N., Pompe, K. ... Higgins, P. G. (2017). Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility. Journal of Global Antimicrobial Resistance, 10., 213-218. doi: 10.1016/j.jgar.2017.07.001

Ladavac, Ranko, et al. "Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility." Journal of Global Antimicrobial Resistance, vol. 10, 2017, pp. 213-218. https://doi.org/10.1016/j.jgar.2017.07.001

Ladavac, Ranko, Branka Bedenić, Mirna Vranić Ladavac, Nada Barišić, Natalie Karčić, Karoline Pompe, Antun Ferenčić, et al. "Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility." Journal of Global Antimicrobial Resistance 10 (2017): 213-218. https://doi.org/10.1016/j.jgar.2017.07.001

Ladavac, R., et al. (2017) 'Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility', Journal of Global Antimicrobial Resistance, 10, pp. 213-218. doi: 10.1016/j.jgar.2017.07.001

Ladavac R, Bedenić B, Vranić Ladavac M, Barišić N, Karčić N, Pompe K, and sur.. Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility. Journal of Global Antimicrobial Resistance [Internet]. 2017 September [cited 2024 November 09];10:213-218. doi: 10.1016/j.jgar.2017.07.001

R. Ladavac, et al., "Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility", Journal of Global Antimicrobial Resistance, vol. 10, pp. 213-218, September 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:282074. [Accessed: 09 November 2024]

Metadata
Title (english)Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
AuthorRanko Ladavac
AuthorBranka Bedenić
AuthorMirna Vranić-Ladavac
AuthorNada Barišić
AuthorNatalie Karčić
AuthorKaroline Pompe
AuthorAntun Ferenčić
AuthorAleksandar Stojanović
AuthorHarald Seifert
AuthorStjepan Katić
AuthorPaul G. Higgins
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Acinetobacter baumannii isolates with three different carbapenem susceptibility patterns: susceptible, intermediate and resistant. Isolates belonging to the same carbapenem susceptibility phenotype exhibited identical susceptibility/resistance patterns to non-β-lactam antibiotics. This prompted us to analyse the mechanisms of carbapenem-resistance and the molecular epidemiology of the isolates. A total of 59 A. baumannii isolates were analysed and grouped according to their susceptibility to imipenem: group 1 were susceptible (N=24), group 2 were intermediate (N=8) and group 3 were resistant (N=27) to imipenem. ----- MATERIAL AND METHODS: PCR and sequencing was used to detect resistance genes. Genotyping of the isolates was performed by PFGE and MLST. ----- RESULTS: Out of 27 resistant isolates, 20 harboured blaOXA-40-like and 7 blaOXA-23-like genes. ISAba1 was found upstream of blaOXA-51 and blaOXA-23 genes. PFGE genotyping demonstrated the existence of three major A. baumannii clones in GH Pula and determination of sequence groups showed that the isolates belonged to international clones commonly associated with multidrug-resistance. MLST (performed on six isolates) showed diverse population structure of isolates belonging to the same cluster, including ST 195, ST 231, ST 775 and ST 1095. ----- CONCLUSIONS: A previous study conducted in 2009-2010 showed that reduced susceptibility to carbapenems in GH Pula was only associated with upregulation of the intrinsic OXA-51 β-lactamase. In this study a shift to isolates with acquired oxacillinases, belonging to two major clones was reported.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Global Antimicrobial Resistance
Numberingvol. 10, pp. 213-218
p-ISSN2213-7165
DOIhttps://doi.org/10.1016/j.jgar.2017.07.001
URN:NBNurn:nbn:hr:105:282074
Publication2017-09
Document URLhttps://doi.org/10.1016/j.jgar.2017.07.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:14:04