prikaz prve stranice dokumenta Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome
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Scientific paper - Original scientific paper
Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome
European Neurology, 77 (2017), 5-6; 253-257. https://doi.org/10.1159/000469707
Habek, Mario; Krbot Skorić, Magdalena; Crnošija, Luka; Gabelić, Tereza; Barun, Barbara; Adamec, Ivan

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Habek, M., Krbot Skorić, M., Crnošija, L., Gabelić, T., Barun, B. & Adamec, I. (2017). Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome. European Neurology, 77. (5-6), 253-257. doi: 10.1159/000469707

Habek, Mario, et al. "Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome." European Neurology, vol. 77, no. 5-6, 2017, pp. 253-257. https://doi.org/10.1159/000469707

Habek, Mario, Magdalena Krbot Skorić, Luka Crnošija, Tereza Gabelić, Barbara Barun and Ivan Adamec. "Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome." European Neurology 77, no. 5-6 (2017): 253-257. https://doi.org/10.1159/000469707

Habek, M., et al. (2017) 'Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome', European Neurology, 77(5-6), pp. 253-257. doi: 10.1159/000469707

Habek M, Krbot Skorić M, Crnošija L, Gabelić T, Barun B, Adamec I. Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome. European Neurology [Internet]. 2017 [cited 2024 April 29];77(5-6):253-257. doi: 10.1159/000469707

M. Habek, M. Krbot Skorić, L. Crnošija, T. Gabelić, B. Barun and I. Adamec, "Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome", European Neurology, vol. 77, no. 5-6, pp. 253-257, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:756368. [Accessed: 29 April 2024]

Metadata
Title (english)Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome
AuthorMario Habek
AuthorMagdalena Krbot Skorić
AuthorLuka Crnošija
AuthorTereza Gabelić
AuthorBarbara Barun
AuthorIvan Adamec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND/AIMS: There have been suggestions that interactions exist between the autonomic nervous system (ANS) and the immune system functions in multiple sclerosis (MS). We aimed to evaluate the ANS dysfunction, more specifically postural orthostatic tachycardia syndrome (POTS), as a possible predictor of conversion to MS in patients with clinically isolated syndrome (CIS). ----- METHODS: In this observational, prospective, longitudinal study, 84 patients were enrolled (56 females, mean age 32.9 ± 8.9 years). Disease activity during a 6-month period was monitored (relapses and/or MRI disease activity indicated by new T2 or T1 enhancing lesions), and the following predictors analyzed: age, Expanded Disability Status Scale, MRI midbrain, pontine or medulla oblongata lesions, and POTS on the head up tilt test. ----- RESULTS: POTS was identified in 8 (9.5%) patients. Of 84 patients, 62 (73.8%) completed the 6-month follow-up, and 28 (45.2%) patients converted to MS. Results of the multivariate regression analysis revealed age (10-year increase) and POTS as significant predictors of early conversion to MS (OR 2.34, 95% CI 1.15-4.78, p = 0.019 and OR 12.40, 95% CI 1.13-136.62, p = 0.040). The logistic model was statistically significant, χ2 (6) = 13.885, p = 0.031. ----- CONCLUSION: POTS may be an indicator of a more active disease course in CIS patients and possibly be used as a prognostic factor.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEuropean Neurology
Numberingvol. 77, no. 5-6, pp. 253-257
p-ISSN0014-3022
DOIhttps://doi.org/10.1159/000469707
URN:NBNurn:nbn:hr:105:756368
Publication2017
Document URLhttp://doi.org/10.1159/000469707
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:18:32