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Scientific paper - Review paper
Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review
Journal of Clinical Psychopharmacology, 37 (2017), 5; 584-589. https://doi.org/10.1097/JCP.0000000000000772
Vuk, Antonia; Baretić, Maja; Matovinović Osvatić, Martina; Filipčić, Igor; Jovanović, Nikolina; Rojnić Kuzman, Martina

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Vuk, A., Baretić, M., Matovinović Osvatić, M., Filipčić, I., Jovanović, N. & Rojnić Kuzman, M. (2017). Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review. Journal of Clinical Psychopharmacology, 37. (5), 584-589. doi: 10.1097/JCP.0000000000000772

Vuk, Antonia, et al. "Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review." Journal of Clinical Psychopharmacology, vol. 37, no. 5, 2017, pp. 584-589. https://doi.org/10.1097/JCP.0000000000000772

Vuk, Antonia, Maja Baretić, Martina Matovinović Osvatić, Igor Filipčić, Nikolina Jovanović and Martina Rojnić Kuzman. "Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review." Journal of Clinical Psychopharmacology 37, no. 5 (2017): 584-589. https://doi.org/10.1097/JCP.0000000000000772

Vuk, A., et al. (2017) 'Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review', Journal of Clinical Psychopharmacology, 37(5), pp. 584-589. doi: 10.1097/JCP.0000000000000772

Vuk A, Baretić M, Matovinović Osvatić M, Filipčić I, Jovanović N, Rojnić Kuzman M. Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review. Journal of Clinical Psychopharmacology [Internet]. 2017 October [cited 2024 December 29];37(5):584-589. doi: 10.1097/JCP.0000000000000772

A. Vuk, M. Baretić, M. Matovinović Osvatić, I. Filipčić, N. Jovanović and M. Rojnić Kuzman, "Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review", Journal of Clinical Psychopharmacology, vol. 37, no. 5, pp. 584-589, October 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:275105. [Accessed: 29 December 2024]

Metadata
Title (english)Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review
AuthorAntonia Vuk
AuthorMaja Baretić
AuthorMartina Matovinović Osvatić
AuthorIgor Filipčić
AuthorNikolina Jovanović
AuthorMartina Rojnić Kuzman
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: The second-generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation, which may be associated with the use of SGAs. This study aims to review published reports of patients with schizophrenia and antipsychotic drug-associated DKA, focusing on the effective management of both conditions. ----- METHODS: Using a predefined search strategy, we searched PubMed and EMBASE from their inception to July 2016. The search terms were related to "diabetic ketoacidosis" and "antipsychotic medication." Case reports, case series, and reviews of case series written in English language were included in the review. ----- RESULTS: Sixty-five reports were analyzed. In most patients who developed antipsychotic-associated DKA, 1 or more suspected antipsychotic medications were discontinued. In 5 cases, a rechallenge test was trialed, and in only 1 case, it resulted in the elevation of blood glucose. The majority was subsequently treated with a different SGA in combination with insulin/oral hypoglycemic agents; although approximately a third of patients had a complete resolution of symptoms or could control diabetes with diet only at the point of discharge. ----- CONCLUSIONS: Patients taking antipsychotic medications should be regularly screened for insulin resistance and educated about potential complications of antipsychotic medications. This will allow clinicians to individualize treatment decisions and reduce iatrogenic contribution to morbidity and mortality. To achieve best treatment outcomes, antipsychotic-induced DKA should be treated jointly by psychiatry and endocrinology teams.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Psychopharmacology
Numberingvol. 37, no. 5, pp. 584-589
p-ISSN0271-0749
DOIhttps://doi.org/10.1097/JCP.0000000000000772
URN:NBNurn:nbn:hr:105:275105
Publication2017-10
Document URLhttps://doi.org/10.1097/JCP.0000000000000772
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:19:43