prikaz prve stranice dokumenta Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retros
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Scientific paper - Original scientific paper
Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study
Frontiers in Psychiatry, 8 (2017); 277. https://doi.org/10.3389/fpsyt.2017.00277
Henigsberg, Neven; Šarac, Helena; Radoš, Marko; Radoš, Milan; Ozretić, David; Foro, Tamara; Erdeljić Turk, Viktorija; Hrabač, Pero; Bajs Janović, Maja; Rak, Benedict; Kalember, Petra

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Henigsberg, N., Šarac, H., Radoš, M., Radoš, M., Ozretić, D., Foro, T. ... Kalember, P. (2017). Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study. Frontiers in Psychiatry, 8., 277. doi: 10.3389/fpsyt.2017.00277

Henigsberg, Neven, et al. "Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study." Frontiers in Psychiatry, vol. 8, 2017, p. 277. https://doi.org/10.3389/fpsyt.2017.00277

Henigsberg, Neven, Helena Šarac, Marko Radoš, Milan Radoš, David Ozretić, Tamara Foro, Viktorija Erdeljić Turk, et al. "Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study." Frontiers in Psychiatry 8 (2017): 277. https://doi.org/10.3389/fpsyt.2017.00277

Henigsberg, N., et al. (2017) 'Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study', Frontiers in Psychiatry, 8, p. 277. doi: 10.3389/fpsyt.2017.00277

Henigsberg N, Šarac H, Radoš M, Radoš M, Ozretić D, Foro T, and sur.. Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study. Frontiers in Psychiatry [Internet]. 2017 December 13 [cited 2024 December 29];8:277. doi: 10.3389/fpsyt.2017.00277

N. Henigsberg, et al., "Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study", Frontiers in Psychiatry, vol. 8, p. 277, December 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:027703. [Accessed: 29 December 2024]

Metadata
Title (english)Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study
AuthorNeven Henigsberg
AuthorHelena Šarac
AuthorMarko Radoš
AuthorMilan Radoš
AuthorDavid Ozretić
AuthorTamara Foro
AuthorViktorija Erdeljić Turk
AuthorPero Hrabač
AuthorMaja Bajs Janović
AuthorBenedict Rak
AuthorPetra Kalember
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: The aim of this study was to evaluate the relationship between changes in proton magnetic resonance spectroscopy (1H-MRS) parameters at the start of the index episode recovery phase and at recurrence in patients with recurrent depression who were treated with prolonged maintenance therapy. ----- Methods: 1H-MRS parameters were analyzed in 48 patients with recurrent depression who required maintenance therapy with antidepressant medication prescribed by a psychiatrist and who continued with the same antidepressant during the maintenance phase, either to recurrence of depression, completion of the 10-year observation period, or the start of the withdrawal phase (tapering-off antidepressant). N-acetylaspartate (NAA), choline-containing metabolites (Cho), creatine (Cr), and glutamine/glutamate were measured at the start of the recovery phase and 6 months later. ----- Results: Recurrent depressive episodes occurred in 20 patients. These individuals had a smaller increase in Cho/Cr after the beginning of the recovery phase compared to the non-recurrent patient group and also exhibited a decreased NAA/Cr ratio. ----- Conclusion: Sustainable NAA and increased Cho levels at the onset of the recovery phase of the index episode are early markers of antidepressant effectiveness associated with a lower risk of major depressive disorder recurrence. The NAA and Cho changes in the non-recurrent group may be attributable to increased brain resilience, contrary to the transient temporal effect observed in subjects who experienced a depressive episode.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Psychiatry
Numberingvol. 8, p. 277
p-ISSN1664-0640
DOIhttps://doi.org/10.3389/fpsyt.2017.00277
URN:NBNurn:nbn:hr:105:027703
Publication2017-12-13
Document URLhttp://doi.org/10.3389/fpsyt.2017.00277
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:21:15