prikaz prve stranice dokumenta HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse
  Download
PDF 521.96 KB
Scientific paper - Original scientific paper
HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse
Human Immunology, 78 (2017), 11-12; 665-671. https://doi.org/10.1016/j.humimm.2017.08.008
Burek Kamenarić, Marija; Maskalan, Marija; Grubić, Zorana; Mikulić, Mirta; Serventi Seiwerth, Ranka; Duraković, Nadira; Vrhovac, Radovan; Štingl Janković, Katarina; Žunec, Renata

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Burek Kamenarić, M., Maskalan, M., Grubić, Z., Mikulić, M., Serventi Seiwerth, R., Duraković, N. ... Žunec, R. (2017). HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse. Human Immunology, 78. (11-12), 665-671. doi: 10.1016/j.humimm.2017.08.008

Burek Kamenarić, Marija, et al. "HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse." Human Immunology, vol. 78, no. 11-12, 2017, pp. 665-671. https://doi.org/10.1016/j.humimm.2017.08.008

Burek Kamenarić, Marija, Marija Maskalan, Zorana Grubić, Mirta Mikulić, Ranka Serventi Seiwerth, Nadira Duraković, Radovan Vrhovac, Katarina Štingl Janković and Renata Žunec. "HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse." Human Immunology 78, no. 11-12 (2017): 665-671. https://doi.org/10.1016/j.humimm.2017.08.008

Burek Kamenarić, M., et al. (2017) 'HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse', Human Immunology, 78(11-12), pp. 665-671. doi: 10.1016/j.humimm.2017.08.008

Burek Kamenarić M, Maskalan M, Grubić Z, Mikulić M, Serventi Seiwerth R, Duraković N, and sur.. HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse. Human Immunology [Internet]. 2017 November [cited 2024 April 28];78(11-12):665-671. doi: 10.1016/j.humimm.2017.08.008

M. Burek Kamenarić, et al., "HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse", Human Immunology, vol. 78, no. 11-12, pp. 665-671, November 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:006478. [Accessed: 28 April 2024]

Metadata
Title (english)HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse
AuthorMarija Burek Kamenarić
AuthorMarija Maskalan
AuthorZorana Grubić
AuthorMirta Mikulić
AuthorRanka Serventi Seiwerth
AuthorNadira Duraković
AuthorRadovan Vrhovac
AuthorKatarina Štingl Janković
AuthorRenata Žunec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The impact of patient/donor matching for HLA-A, -B, -C, -DRB1 and -DQB1 genes in hematopoietic stem cell transplantation (HSCT) is well-recognized, but typing for additional genes, such as HLA-DPB1, is still controversial. Based on defined T-cell epitope (TCE) groups, all HLA-DPB1 mismatches can be classified as permissive or non-permissive. In this retrospective study we analysed 82 patient-matched unrelated donor (MUD) pairs who underwent HSCT, and explored the impact of HLA-DPB1 matches, permissive and non-permissive mismatches on transplantation outcomes. Patient-MUD pairs matched for HLA-DPB1 alleles in univariate analysis were associated with a significantly higher incidence of disease relapse compared to pairs who were permissive/non-permissive HLA-DPB1 mismatched according to the TCE3 and TCE4 algorithms (P=0.025 and P=0.026, respectively), although the significance was lost in multivariate analysis. The analysis did not reveal any significant influence of HLA-DPB1 alleles on overall survival (OS), non-relapse mortality (NRM) or graft-versus-host disease (GvHD) incidence. In conclusion, our study presents evidence that HLA-DPB1 matching influenced the relapse rate in patients after HSCT so the HLA-DPB1 alleles should be implemented in the MUD search algorithm as a transplantation determinant.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleHuman Immunology
Numberingvol. 78, no. 11-12, pp. 665-671
p-ISSN0198-8859
DOIhttps://doi.org/10.1016/j.humimm.2017.08.008
URN:NBNurn:nbn:hr:105:006478
Publication2017-11
Document URLhttps://doi.org/10.1016/j.humimm.2017.08.008
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:22:42