prikaz prve stranice dokumenta Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study
  Download
PDF 623.14 KB
Scientific paper - Original scientific paper
Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study
Croatian Medical Journal, 48 (2007), 6; 822-830. https://doi.org/10.3325/cmj.2007.6.822
Sjekavica, Ivica; Barbarić-Babić, Vinka; Krznarić, Željko; Molnar, Melita; Čuković-Čavka, Silvija; Štern-Padovan, Ranka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Sjekavica, I., Barbarić Babić, V., Krznarić, Ž., Molnar, M., Čuković Čavka, S. & Štern Padovan, R. (2007). Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study. Croatian Medical Journal, 48. (6), 822-830. doi: 10.3325/cmj.2007.6.822

Sjekavica, Ivica, et al. "Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study." Croatian Medical Journal, vol. 48, no. 6, 2007, pp. 822-830. https://doi.org/10.3325/cmj.2007.6.822

Sjekavica, Ivica, Vinka Barbarić Babić, Željko Krznarić, Melita Molnar, Silvija Čuković Čavka and Ranka Štern Padovan. "Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study." Croatian Medical Journal 48, no. 6 (2007): 822-830. https://doi.org/10.3325/cmj.2007.6.822

Sjekavica, I., et al. (2007) 'Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study', Croatian Medical Journal, 48(6), pp. 822-830. doi: 10.3325/cmj.2007.6.822

Sjekavica I, Barbarić Babić V, Krznarić Ž, Molnar M, Čuković Čavka S, Štern Padovan R. Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study. Croatian Medical Journal [Internet]. 2007 December [cited 2024 May 06];48(6):822-830. doi: 10.3325/cmj.2007.6.822

I. Sjekavica, V. Barbarić Babić, Ž. Krznarić, M. Molnar, S. Čuković Čavka and R. Štern Padovan, "Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study", Croatian Medical Journal, vol. 48, no. 6, pp. 822-830, December 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:100528. [Accessed: 06 May 2024]

Metadata
Title (english)Assessment of Crohn's disease activity by doppler ultrasound of superior mesenteric artery and mural arteries in thickened bowel wall: cross-sectional study
AuthorIvica Sjekavica
AuthorVinka Barbarić-Babić
AuthorŽeljko Krznarić
AuthorMelita Molnar
AuthorSilvija Čuković-Čavka
AuthorRanka Štern-Padovan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To define sensitive and reliable Doppler parameters for measurements in the superior mesenteric artery and mural arteries of affected bowel loops used in the assessment of Crohn disease activity. ----- METHODS: We performed cross-sectional study at a tertiary care setting in Zagreb, Croatia, between January 2001 and March 2005. We measured arterial flow in the superior mesenteric artery and affected bowel wall in 138 patients with Crohn disease (74 with active, 64 with inactive disease) and 67 healthy volunteers. The disease activity was determined by the clinical examination, Crohn disease activity index, and standard laboratory tests. Superior mesenteric artery color and pulsed Doppler parameters were peak systolic velocity, end-diastolic velocity, resistance index, mean velocity flow, cross-sectional area, and flow volume. When gut mural vessels were identified, we performed spectral analysis of mural arteries by pulsed Doppler, with a measurement of resistance index. ----- RESULTS: The measurements in the superior mesenteric artery showed statistically and clinically significant difference in flow volume in active group, compared with inactive and control groups (C+/-Q=564+/-263 mL/min for active, 421+/-157 for inactive and 416+/-248 for control group). Affected bowel loops analysis showed significant difference between inactive and active Crohn disease group in wall thickness (3.1+/-1.4 vs 5.0+/-1.8 mm, P<0.001, Mann-Whitney test) while all participants from control group had thickness below 2mm. Intensity of color Doppler signals was different for all groups (P<0.001, chi(2) test) with the highest level of hyperemia in the active group. Resistance index measurements of mural arteries in bowel wall revealed differences between all three groups (0.61+/-0.05 in active group, 0.71+/-0.05 in the inactive group and 0.80+/-0.11 in the control group, P<0.001, Kruskal-Wallis test). ----- CONCLUSION: Intensity of color Doppler signals and resistance index measurements of mural arteries in the thickened bowel wall can be used as quantitative diagnostic tool in the assessment of Crohn disease activity.
Abstract (croatian)
Cilj: Odrediti osjetljive i pouzdane Dopplerske parametre za mjerenja u gornjoj mezenterijskoj arteriji i arterijama stijenke zahvaćenih crijevnih vijuga pri procjeni aktivnosti Crohnove bolesti. ----- Postupci: U ustanovi tercijarne zdravstvene skrbi u Zagrebu, Hrvatska, proveli smo presječno istraživanje između siječnja 2001 i ožujka 2005. U 138 bolesnika s Crohnovom bolešću (74 s aktivnim i 64 s ne-aktivnim oblikom bolesti), te u 67 zdravih dragovoljaca, mjerili smo arterijski krvni protok u gornjoj mezenteriskoj arteriji i arterijama zahvaćene crijevne stijenke. Bolest je dijagnosticirana kliničkim pregledom , indeksom aktivnosti Crohnove bolesti i standardnim laboratorijskim testovima. Mjereni parametri za gornju mezenterijsku arteriju određeni su Dopplerom u boji i pulsnim Dopplerom, kao vršna sistolička brzina krvi, brzina krvi na kraju dijastole, indeks otpora, srednja brzina protoka, površina presjeka žile i veličina protoka. U slučajevima kada smo uspjeli identificirati žile u crijevnoj stijenci, napravili smo spektralnu analizu arterija u stijenci s pomoću pulsnoga Dopplera, a mjerenjem indeksa otpora protoku krvi. ----- Rezultati: Mjerenja u gornjoj mezenterijskoj arteriji pokazala su statistički i klinički značajnu razliku veličine protoka krvi u skupini bolesnika s aktivnom bolešću u usporedbi s bolesnicima bez aktivne bolesti i kontrolnim sudionicima (C±Q=564±263 mL/min za aktivni oblik bolesti, 421±157 za ne-aktivni, te 416±248 za kontrolnu skupinu). Analiza zahvaćenih crijevnih vijuga pokazala je značajnu razliku između skupina bolesnika s ne-aktivnim i aktivnim oblikom Crohnove bolesti u debljini crijevne stijenke (3,1±1,4 vs 5,0±1,8 mm, P<0,001, test Mann Whitney), dok je u svih pripadnika kontrolne skupine debljina stijenke bila manja od 2 mm. Intenzitet Dopplerskog signala u boji razlikovala se u svim skupinama (P<0,001, χ2 test), s najvećom hiperemijom u skupini bolesnika s aktivnom bolešću. Mjerenje indeksa otpora protoku u arterijama iz crijevne stijenke također je otkrilo razlike među trima skupinama (0,61±0,05 u skupini s aktivnom bolešću, 0,71±0,05 u skupini s ne-aktivnom bolešću i 0,80±0,11 u kontrolnoj skupini, P<0,001, test Kruskal-Wallis). ----- Zaključak: Intenzitet Dopplerskih signala i mjerenja indeksa otpora protoku krvi u arterijama zadebljane crijevne stijenke mogu poslužiti kao kvantitativna dijagnostička mjera u procjeni aktivnosti Crohnove bolesti.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 48, no. 6, pp. 822-830
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2007.6.822
URN:NBNurn:nbn:hr:105:100528
Publication2007-12
Document URLhttp://www.cmj.hr/2007/48/6/18074417.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:48:32