prikaz prve stranice dokumenta Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective
  Download
PDF 193.5 KB
Scientific paper - Original scientific paper
Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study
Croatian Medical Journal, 59 (2018), 5; 244-252. https://doi.org/10.3325/cmj.2018.59.244
Henigsberg, Neven; Savić, Aleksandar; Radoš, Marko; Šarac, Helena; Radoš, Milan; Ozretić, David; Bajs Janović, Maja; Erdeljić Turk, Viktorija; Šečić, Ana; Kalember, Petra; Hrabač, Pero

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Henigsberg, N., Savić, A., Radoš, M., Šarac, H., Radoš, M., Ozretić, D. ... Hrabač, P. (2018). Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study. Croatian Medical Journal, 59. (5), 244-252. doi: 10.3325/cmj.2018.59.244

Henigsberg, Neven, et al. "Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study." Croatian Medical Journal, vol. 59, no. 5, 2018, pp. 244-252. https://doi.org/10.3325/cmj.2018.59.244

Henigsberg, Neven, Aleksandar Savić, Marko Radoš, Helena Šarac, Milan Radoš, David Ozretić, Maja Bajs Janović, et al. "Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study." Croatian Medical Journal 59, no. 5 (2018): 244-252. https://doi.org/10.3325/cmj.2018.59.244

Henigsberg, N., et al. (2018) 'Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study', Croatian Medical Journal, 59(5), pp. 244-252. doi: 10.3325/cmj.2018.59.244

Henigsberg N, Savić A, Radoš M, Šarac H, Radoš M, Ozretić D, and sur.. Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study. Croatian Medical Journal [Internet]. 2018 October 31 [cited 2024 April 30];59(5):244-252. doi: 10.3325/cmj.2018.59.244

N. Henigsberg, et al., "Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study", Croatian Medical Journal, vol. 59, no. 5, pp. 244-252, October 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:680821. [Accessed: 30 April 2024]

Metadata
Title (english)Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study
AuthorNeven Henigsberg
AuthorAleksandar Savić
AuthorMarko Radoš
AuthorHelena Šarac
AuthorMilan Radoš
AuthorDavid Ozretić
AuthorMaja Bajs Janović
AuthorViktorija Erdeljić Turk
AuthorAna Šečić
AuthorPetra Kalember
AuthorPero Hrabač
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim: To evaluate the relationship between the dynamics of proton magnetic resonance spectroscopy (1H-MRS) brain metabolite levels at the beginning of the recovery phase of the index depressive episode and the time to the recurrence of depression. Methods: This retrospective cohort study analyzed the changes in N-acetyl aspartate (NAA), choline (Cho), and glutamate-glutamine in 48 patients with recurrent depression treated with maintenance antidepressant monotherapy at a stable dose. 1H-MRS was performed at the start of the recovery phase and 6 months later. 1H-MRS parameters, index episode descriptors, and depressive disorder course were analyzed by Cox proportional hazards model. Results: NAA and Cho decrease six months after the beginning of the recovery period were time-independent risk factors for depressive episode recurrence. Hazard ratio associated with NAA decrease was 2.02 (95% confidence interval 1.06-3.84) and that associated with Cho decrease was 2.06 (95% confidence interval 1.02-4.17). These changes were not related to symptoms severity, as Montgomery-Asberg Depression Scale score remained generally unchanged (mean -0.01; standard deviation 1.6) over the first 6 months of recovery. Conclusion: Patients receiving maintenance antidepressant therapy after recovery who experience a decrease in NAA or Cho levels early in the recovery phase have a double risk of depressive episode recurrence. Sustained NAA and Cho levels at the beginning of the recovery phase may indicate increased brain resilience conferred by antidepressant therapy, while NAA and Cho decrease may indicate only the trait-related temporal effect of therapy in another stratum of patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 59, no. 5, pp. 244-252
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2018.59.244
URN:NBNurn:nbn:hr:105:680821
Publication2018-10-31
Document URLhttps://doi.org/10.3325/cmj.2018.59.244
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:49:04