prikaz prve stranice dokumenta Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis
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Scientific paper - Original scientific paper
Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis
Croatian Medical Journal, 59 (2018), 5; 224-231. https://doi.org/10.3325/cmj.2018.59.224
Gašparović, Hrvoje; Svetina, Lucija; Lončarić, Filip; Ljubas, Jana; Čikeš, Maja; Biočina, Bojan; Miličić, Davor

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Gašparović, H., Svetina, L., Lončarić, F., Ljubas, J., Čikeš, M., Biočina, B. & Miličić, D. (2018). Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis. Croatian Medical Journal, 59. (5), 224-231. doi: 10.3325/cmj.2018.59.224

Gašparović, Hrvoje, et al. "Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis." Croatian Medical Journal, vol. 59, no. 5, 2018, pp. 224-231. https://doi.org/10.3325/cmj.2018.59.224

Gašparović, Hrvoje, Lucija Svetina, Filip Lončarić, Jana Ljubas, Maja Čikeš, Bojan Biočina and Davor Miličić. "Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis." Croatian Medical Journal 59, no. 5 (2018): 224-231. https://doi.org/10.3325/cmj.2018.59.224

Gašparović, H., et al. (2018) 'Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis', Croatian Medical Journal, 59(5), pp. 224-231. doi: 10.3325/cmj.2018.59.224

Gašparović H, Svetina L, Lončarić F, Ljubas J, Čikeš M, Biočina B, and sur.. Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis. Croatian Medical Journal [Internet]. 2018 October 31 [cited 2024 April 29];59(5):224-231. doi: 10.3325/cmj.2018.59.224

H. Gašparović, et al., "Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis", Croatian Medical Journal, vol. 59, no. 5, pp. 224-231, October 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:805999. [Accessed: 29 April 2024]

Metadata
Title (english)Preponderance of microbial isolates among heart transplantation recipients requiring renal replacement therapy: a propensity score-adjusted analysis
AuthorHrvoje Gašparović
AuthorLucija Svetina
AuthorFilip Lončarić
AuthorJana Ljubas
AuthorMaja Čikeš
AuthorBojan Biočina
AuthorDavor Miličić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim: To assess the association between renal replacement therapy (RRT) and post-transplant infection incidence. Methods: This single-center retrospective cohort study included 158 patients who underwent heart transplantation (HTx) in our center from 2008 to 2016, survived beyond the first post-procedural day, and had available microbial data. The patients were dichotomized according to the need for periprocedural RRT. Twenty-seven patients in RRT group had lower preoperative creatinine clearance, greater body mass index, and higher likelihood of having diabetes. Propensity score adjustment was used to account for multiple covariates. The primary outcome measure was the presence of bacteremia in patients with and without the need for RRT. The secondary outcome measures were the presence of microbial isolates from any culture and clinical outcome data. Results: Unadjusted analysis showed that the RRT group had higher incidence of any positive microbial isolate (93% vs 73%; odds ratio [OR] 4.77, 95% confidence interval [CI] 1.01-30.53; P = 0.026) and an increased susceptibility to bacteremia (50% vs 22%; OR 3.50, 95% CI 1.28-9.67; P = 0.012). Propensity score-adjusted analysis corroborated the between-group difference in positive blood cultures (OR 3.97, 95% CI 1.28-12.32; P = 0.017). There was no difference in the incidence of total microbial isolates between the groups (OR 4.55, 95% CI 0.90-23.05; P = 0.067). Conclusions: Patients requiring RRT after HTx had an increased susceptibility to infections via various portals of entry, predominantly due to an increase in blood-borne infections. Understanding the underlying conditions leading to infection-related morbidity is important for infection control and prevention.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 59, no. 5, pp. 224-231
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2018.59.224
URN:NBNurn:nbn:hr:105:805999
Publication2018-10-31
Document URLhttp://doi.org/10.3325/cmj.2018.59.224
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:48:43