prikaz prve stranice dokumenta Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia
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Scientific paper - Original scientific paper
Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia
Infection, Genetics and Evolution, 43 (2016); 74-82. https://doi.org/10.1016/j.meegid.2016.05.011
Bedenić, Branka; Sardelić, Sanda; Luxner, Josefa; Bošnjak, Zrinka; Varda-Brkić, Dijana; Lukić-Grlić, Amarela; Mareković, Ivana; Frančula-Zaninović, Sonja; Krilanović, Marija; Šijak, Dorotea; Grisold, Andrea; Zarfel, Gernot

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Bedenić, B., Sardelić, S., Luxner, J., Bošnjak, Z., Varda Brkić, D., Lukić Grlić, A. ... Zarfel, G. (2016). Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia. Infection, Genetics and Evolution, 43., 74-82. doi: 10.1016/j.meegid.2016.05.011

Bedenić, Branka, et al. "Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia." Infection, Genetics and Evolution, vol. 43, 2016, pp. 74-82. https://doi.org/10.1016/j.meegid.2016.05.011

Bedenić, Branka, Sanda Sardelić, Josefa Luxner, Zrinka Bošnjak, Dijana Varda Brkić, Amarela Lukić Grlić, Ivana Mareković, et al. "Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia." Infection, Genetics and Evolution 43 (2016): 74-82. https://doi.org/10.1016/j.meegid.2016.05.011

Bedenić, B., et al. (2016) 'Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia', Infection, Genetics and Evolution, 43, pp. 74-82. doi: 10.1016/j.meegid.2016.05.011

Bedenić B, Sardelić S, Luxner J, Bošnjak Z, Varda Brkić D, Lukić Grlić A, and sur.. Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia. Infection, Genetics and Evolution [Internet]. 2016 September [cited 2024 December 27];43:74-82. doi: 10.1016/j.meegid.2016.05.011

B. Bedenić, et al., "Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia", Infection, Genetics and Evolution, vol. 43, pp. 74-82, September 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:052008. [Accessed: 27 December 2024]

Metadata
Title (english)Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia
AuthorBranka Bedenić
AuthorSanda Sardelić
AuthorJosefa Luxner
AuthorZrinka Bošnjak
AuthorDijana Varda-Brkić
AuthorAmarela Lukić-Grlić
AuthorIvana Mareković
AuthorSonja Frančula-Zaninović
AuthorMarija Krilanović
AuthorDorotea Šijak
AuthorAndrea Grisold
AuthorGernot Zarfel
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Carbapenemases involved in acquired carbapenem resistance in Enterobacteriaceae belong to Ambler class A serin β-lactamases, class B metallo-β-lactamases (MBL) or class D OXA-48-like β-lactamases. The aim of the present study was to analyse the molecular epidemiology and the mechanisms and routes of spread of class B and class D carbapenemases in Croatia. In total 68 isolates were analyzed. Antibiotic susceptibility was determined by broth microdilution method. PCR was used to detect antibiotic-resistance genes. Genotyping was performed by rep-PCR and MLST. Sixty-five isolates were found to harbour VIM-1 carbapenemase, seven of which were positive also for NDM-1, while two strains harboured only NDM-1. OXA-48 was detected in three isolates, two of which coproduced VIM-1. Thirty-six strains possessed additional CTX-M-15 β-lactamase whereas 64 were positive for TEM-1. CMY was found in 18 Citrobacter freundii isolates and DHA-1 in one Enterobacter cloacae isolate. Four different plasmid-incompatibility groups were found: A/C, L/M, N and FIIAs. Unlike C. freundii and E. cloacae, Klebsiella pneumoniae showed high diversity of rep-PCR patterns. E. cloacae and C. freundii predominantly belonged to one large clone which was allocated to ST105 and ST24, respectively. Three different types of carbapenemases were identified showing the complexity of CRE in Croatia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInfection, Genetics and Evolution
Numberingvol. 43, pp. 74-82
p-ISSN15671348
DOIhttps://doi.org/10.1016/j.meegid.2016.05.011
URN:NBNurn:nbn:hr:105:052008
Publication2016-09
Document URLhttps://doi.org/10.1016/j.meegid.2016.05.011
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:49:14