prikaz prve stranice dokumenta Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study
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Scientific paper - Case study
Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study
Croatian Medical Journal, 59 (2018), 5; 232-243. https://doi.org/doi:10.3325/cmj.2018.59.232
Ravić, Katja Grubelic; Paić, Frane; Vucelić, Boris; Brinar, Marko; Čuković-Čavka, Silvija; Božina, Nada; Krznarić, Željko; Kalauz, Mirjana; Bešić, Dino; Martić, Tamara Nikuševa

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Ravić, K. G., Paić, F., Vucelić, B., Brinar, M., Čuković Čavka, S., Božina, N. ... Martić, T. N. (2018). Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study. Croatian Medical Journal, 59. (5), 232-243. doi: doi:10.3325/cmj.2018.59.232

Ravić, Katja Grubelic, et al. "Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study." Croatian Medical Journal, vol. 59, no. 5, 2018, pp. 232-243. https://doi.org/doi:10.3325/cmj.2018.59.232

Ravić, Katja Grubelic, Frane Paić, Boris Vucelić, Marko Brinar, Silvija Čuković Čavka, Nada Božina, Željko Krznarić, Mirjana Kalauz, Dino Bešić and Tamara Nikuševa Martić. "Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study." Croatian Medical Journal 59, no. 5 (2018): 232-243. https://doi.org/doi:10.3325/cmj.2018.59.232

Ravić, K. G., et al. (2018) 'Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study', Croatian Medical Journal, 59(5), pp. 232-243. doi: doi:10.3325/cmj.2018.59.232

Ravić KG, Paić F, Vucelić B, Brinar M, Čuković Čavka S, Božina N, and sur.. Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study. Croatian Medical Journal [Internet]. 2018 October 31 [cited 2024 April 28];59(5):232-243. doi: doi:10.3325/cmj.2018.59.232

K. G. Ravić, et al., "Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study", Croatian Medical Journal, vol. 59, no. 5, pp. 232-243, October 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:059274. [Accessed: 28 April 2024]

Metadata
Title (english)Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study
AuthorKatja Grubelic Ravić
AuthorFrane Paić
AuthorBoris Vucelić
AuthorMarko Brinar
AuthorSilvija Čuković-Čavka
AuthorNada Božina
AuthorŽeljko Krznarić
AuthorMirjana Kalauz
AuthorDino Bešić
AuthorTamara Nikuševa Martić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim: To analyze the distribution of SLC6A4 gene polymorphisms in Crohn's disease (CD) patients and their association with the disease. Methods: We evaluated the presence/absence of promoter (5-HTTLPR, rs25531) and intron 2 (STin2 VNTR) polymorphic variants of SLC6A4 gene in a retrospective case-control study including 192 CD patients and 157 healthy controls (HC). Genotyping was performed by polymerase chain reaction. The association of polymorphisms with CD and its clinical subtypes was analyzed using χ2 and Fisher exact test, binary logistic regression, and haplotype analysis. Results: CD patients and healthy controls had similar sex (88 [45.8%] vs 84 [53.5%] women, respectively; P=0.154) and age (41.3±12.8 years vs 41.7±8.8 years, respectively, P=0.091) distribution. Significant differences were observed in the STin2 genotype and allele distribution between CD patients and healthy controls (P=0.003 and P=0.002, respectively) and between the corresponding female subgroups (P=0.004 and P=0.007, respectively), with a significant negative association of biallelic ss (STin2.9 and Stin2.10) STin2 genotype with CD (P=0.013, age- and sex-adjusted odds ratio [OR] 0.5, 95% confidence interval [CI] 0.29-0.86; women: P=0.006, age-adjusted OR 0.32, 95% CI 0.14-0.72) and a significantly higher S-STin2.12 (5-HTTLPR/rs25531: S-STin2: STin2.12) haplotype distribution in CD patients (P=0.004, OR 1.62, 95% CI 1.16-2.26). There was no significant association between 5-HTTLRP and rs25531 genotype or allele frequencies and CD and between any SLC6A4 polymorphic loci with clinical CD subtypes. Conclusion: STin2 VNTR polymorphism of SLC6A4 gene may contribute to CD pathogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 59, no. 5, pp. 232-243
p-ISSN0353-9504
DOIhttps://doi.org/doi:10.3325/cmj.2018.59.232
URN:NBNurn:nbn:hr:105:059274
Publication2018-10-31
Document URLhttp://doi.org/10.3325/cmj.2018.59.232
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:50:20