prikaz prve stranice dokumenta Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study
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Scientific paper - Original scientific paper
Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study
Journal of Neurology, 254 (2007), 12; 1676-1683. https://doi.org/10.1007/s00415-007-0611-y
Klepac, Nataša; Relja, Maja; Klepac, Ratimir; Hećimović, Silva; Babić, Tomislav; Trkulja, Vladimir

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Klepac, N., Relja, M., Klepac, R., Hećimović, S., Babić, T. & Trkulja, V. (2007). Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study. Journal of Neurology, 254. (12), 1676-1683. doi: 10.1007/s00415-007-0611-y

Klepac, Nataša, et al. "Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study." Journal of Neurology, vol. 254, no. 12, 2007, pp. 1676-1683. https://doi.org/10.1007/s00415-007-0611-y

Klepac, Nataša, Maja Relja, Ratimir Klepac, Silva Hećimović, Tomislav Babić and Vladimir Trkulja. "Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study." Journal of Neurology 254, no. 12 (2007): 1676-1683. https://doi.org/10.1007/s00415-007-0611-y

Klepac, N., et al. (2007) 'Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study', Journal of Neurology, 254(12), pp. 1676-1683. doi: 10.1007/s00415-007-0611-y

Klepac N, Relja M, Klepac R, Hećimović S, Babić T, Trkulja V. Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study. Journal of Neurology [Internet]. 2007 December [cited 2024 November 23];254(12):1676-1683. doi: 10.1007/s00415-007-0611-y

N. Klepac, M. Relja, R. Klepac, S. Hećimović, T. Babić and V. Trkulja, "Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study", Journal of Neurology, vol. 254, no. 12, pp. 1676-1683, December 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:833899. [Accessed: 23 November 2024]

Metadata
Title (english)Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study
AuthorNataša Klepac
AuthorMaja Relja
AuthorRatimir Klepac
AuthorSilva Hećimović
AuthorTomislav Babić
AuthorVladimir Trkulja
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND : Animal data and postmortem studies suggest a role of oxidative stress in the Huntington's disease (HD), but in vivo human studies have been scarce. ----- AIM : To assess the presence of oxidative stress in HD patients and its occurrence relative to clinical symptoms. ----- METHODS : Oxidative stress markers were determined in plasma of HD patients (n = 19), asymptomatic HD gene carriers (with > 38 CAG repeats) (n = 11) and their respective sex and agematched healthy controls (n = 47 and n = 22) in a cross-sectional study. ----- RESULTS : With adjustment for age and sex, HD patients had higher plasma lipid peroxidation (LP) levels (ratio 1.20, 95% CI 1.09 to 1.32, p < 0.001) and lower reduced glutathione (GSH) levels (ratio 0.72, CI 0.55 to 0.94, p = 0.011) than their age and sex-matched controls. Although considerably younger, HD gene carriers did not differ from HD patients regarding LP and GSH levels, and had higher plasma LP (ratio 1.16, CI 1.02 to 1.32, p = 0.016) and lower GSH than their matched controls (ratio 0.73, CI 0.5 to 1.05). They had higher LP (ratio 1.18, CI 1.02 to 1.34, p = 0.019) and lower GSH (ratio 0.75, CI 0.51 to 1.11) than the healthy subjects matched to HD patients. ----- CONCLUSIONS : Oxidative stress is more pronounced in HD patients and asymptomatic HD gene carriers than in healthy subjects. Differences in plasma LP and GSH are in line with the brain findings in animal models of HD. Data suggest that oxidative stress occurs before the onset of the HD symptoms.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neurology
Numberingvol. 254, no. 12, pp. 1676-1683
p-ISSN0340-5354
DOIhttps://doi.org/10.1007/s00415-007-0611-y
URN:NBNurn:nbn:hr:105:833899
Publication2007-12
Document URLhttps://doi.org/10.1007/s00415-007-0611-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:52:52