prikaz prve stranice dokumenta Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy
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Scientific paper - Original scientific paper
Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy
Scientific Reports, 8 (2018), 1; 12909. https://doi.org/10.1038/s41598-018-31054-9
Isaković, Jasmina; Dobbs-Dixon, Ian; Chaudhury, Dipesh; Mitrečić, Dinko

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Isaković, J., Dobbs Dixon, I., Chaudhury, D. & Mitrečić, D. (2018). Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy. Scientific Reports, 8. (1), 12909. doi: 10.1038/s41598-018-31054-9

Isaković, Jasmina, et al. "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy." Scientific Reports, vol. 8, no. 1, 2018, p. 12909. https://doi.org/10.1038/s41598-018-31054-9

Isaković, Jasmina, Ian Dobbs Dixon, Dipesh Chaudhury and Dinko Mitrečić. "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy." Scientific Reports 8, no. 1 (2018): 12909. https://doi.org/10.1038/s41598-018-31054-9

Isaković, J., et al. (2018) 'Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy', Scientific Reports, 8(1), p. 12909. doi: 10.1038/s41598-018-31054-9

Isaković J, Dobbs Dixon I, Chaudhury D, Mitrečić D. Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy. Scientific Reports [Internet]. 2018 August 27 [cited 2024 November 29];8(1):12909. doi: 10.1038/s41598-018-31054-9

J. Isaković, I. Dobbs Dixon, D. Chaudhury and D. Mitrečić, "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy", Scientific Reports, vol. 8, no. 1, p. 12909, August 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:694719. [Accessed: 29 November 2024]

Metadata
Title (english)Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy
AuthorJasmina Isaković
AuthorIan Dobbs-Dixon
AuthorDipesh Chaudhury
AuthorDinko Mitrečić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
All major processes in the nervous system depend on interactions between cells and nerve fibers. In this work we present a novel model of inhomogeneous electromagnetic fields originating from nerve fibers and delineate their influence on cells. By expanding Hodgkin-Huxley's applied current into axial current, governed by by [Formula: see text], we reveal that cell-with-neuron interactions are regulated by the strength of the electromagnetic fields, which are homogeneous up to 2.066 μm or 6.606 μm away from neurilemma and axolemma, respectively. At the nodes of Ranvier, these fields reach strengths of 3.0 × 10-12T, while at the myelinated segments they only peak at 2.3 × 10-12T. These are the same fields which are, due to inhomogeneity, detected as 1,000 times weaker by magnetoencephalography. Considering the widespread occurrence of neurodegenerative disorders, our model reveals that a 50% demyelination increases the field strength by 0.35 × 10-12T, while a complete demyelination increases it by 0.7 × 10-12T. Since this suggests that the inhomogeneous electromagnetic fields around neurons play a role in physiological and pathological processes, including cell-to-neuron and cell-to-cell communication, their improved understanding opens up new therapeutic strategies based on electromagnetic field modulation or cell's surface charge alteration.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 8, no. 1, p. 12909
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-018-31054-9
URN:NBNurn:nbn:hr:105:694719
Publication2018-08-27
Document URLhttps://doi.org/10.1038/s41598-018-31054-9
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:56:04