prikaz prve stranice dokumenta Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort
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Scientific paper - Original scientific paper
Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort
Brain and Behavior, 8 (2018), 11; e01128. https://doi.org/10.1002/brb3.1128
Babić Leko, Mirjana; Willumsen, Nanet; Nikolac Perković, Matea; Klepac, Nataša; Borovečki, Fran; Hof, Patrick R.; Sonicki, Zdenko; Pivac, Nela; de Silva, Rohan; Šimić, Goran

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Babić Leko, M., Willumsen, N., Nikolac Perković, M., Klepac, N., Borovečki, F., Hof, P. R. ... Šimić, G. (2018). Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort. Brain and Behavior, 8. (11). doi: 10.1002/brb3.1128

Babić Leko, Mirjana, et al. "Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort." Brain and Behavior, vol. 8, no. 11, 2018. https://doi.org/10.1002/brb3.1128

Babić Leko, Mirjana, Nanet Willumsen, Matea Nikolac Perković, Nataša Klepac, Fran Borovečki, Patrick R. Hof, Zdenko Sonicki, Nela Pivac, Rohan de Silva and Goran Šimić. "Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort." Brain and Behavior 8, no. 11 (2018). https://doi.org/10.1002/brb3.1128

Babić Leko, M., et al. (2018) 'Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort', Brain and Behavior, 8(11). doi: 10.1002/brb3.1128

Babić Leko M, Willumsen N, Nikolac Perković M, Klepac N, Borovečki F, Hof PR, and sur.. Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort. Brain and Behavior [Internet]. 2018 November [cited 2024 December 30];8(11). doi: 10.1002/brb3.1128

M. Babić Leko, et al., "Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort", Brain and Behavior, vol. 8, no. 11, November 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:531983. [Accessed: 30 December 2024]

Metadata
Title (english)Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort
AuthorMirjana Babić Leko
AuthorNanet Willumsen
AuthorMatea Nikolac Perković
AuthorNataša Klepac
AuthorFran Borovečki
AuthorPatrick R. Hof
AuthorZdenko Sonicki
AuthorNela Pivac
AuthorRohan de Silva
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
INTRODUCTION: Alzheimer's disease (AD) is the world leading cause of dementia. Early detection of AD is essential for faster and more efficacious usage of therapeutics and preventive measures. Even though it is well known that one ε4 allele of apolipoprotein E gene increases the risk for sporadic AD five times, and that two ε4 alleles increase the risk 20 times, reliable genetic markers for AD are not yet available. Previous studies have shown that microtubule-associated protein tau (MAPT) gene polymorphisms could be associated with increased risk for AD. ----- METHODS: The present study included 113 AD patients and 53 patients with mild cognitive impairment (MCI), as well as nine healthy controls (HC) and 53 patients with other primary causes of dementia. The study assessed whether six MAPT haplotype-tagging polymorphisms (rs1467967, rs242557, rs3785883, rs2471738, del-In9, and rs7521) and MAPT haplotypes are associated with AD pathology, as measured by cerebrospinal fluid (CSF) AD biomarkers amyloid β1-42 (Aβ1-42 ), total tau (t-tau), tau phosphorylated at epitopes 181 (p-tau181 ), 199 (p-tau199 ), and 231 (p-tau231 ), and visinin-like protein 1 (VILIP-1). ----- RESULTS: Significant increases in t-tau and p-tau CSF levels were found in patients with AG and AA MAPT rs1467967 genotype, CC MAPT rs2471738 genotype and in patients with H1H2 or H2H2 MAPT haplotype. ----- CONCLUSIONS: These results indicate that MAPT haplotype-tagging polymorphisms and MAPT haplotypes should be further tested as potential genetic biomarkers of AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBrain and Behavior
Numberingvol. 8, no. 11, e01128
p-ISSN2162-3279
DOIhttps://doi.org/10.1002/brb3.1128
URN:NBNurn:nbn:hr:105:531983
Publication2018-11
Document URLhttps://doi.org/10.1002/brb3.1128
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:57:58