prikaz prve stranice dokumenta The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia
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Scientific paper - Original scientific paper
The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia
Journal of Photochemistry and Photobiology B: Biology, 89 (2007), 2-3; 63-69. https://doi.org/10.1016/j.jphotobiol.2007.09.002
Ljubičić, Đulijano; Stipčević, Tamara; Pivac, Nela; Jakovljević, Miro; Muck-Šeler, Dorotea

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Ljubičić, Đ., Stipčević, T., Pivac, N., Jakovljević, M. & Muck Šeler, D. (2007). The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia. Journal of Photochemistry and Photobiology B: Biology, 89. (2-3), 63-69. doi: 10.1016/j.jphotobiol.2007.09.002

Ljubičić, Đulijano, et al. "The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia." Journal of Photochemistry and Photobiology B: Biology, vol. 89, no. 2-3, 2007, pp. 63-69. https://doi.org/10.1016/j.jphotobiol.2007.09.002

Ljubičić, Đulijano, Tamara Stipčević, Nela Pivac, Miro Jakovljević and Dorotea Muck Šeler. "The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia." Journal of Photochemistry and Photobiology B: Biology 89, no. 2-3 (2007): 63-69. https://doi.org/10.1016/j.jphotobiol.2007.09.002

Ljubičić, Đ., et al. (2007) 'The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia', Journal of Photochemistry and Photobiology B: Biology, 89(2-3), pp. 63-69. doi: 10.1016/j.jphotobiol.2007.09.002

Ljubičić Đ, Stipčević T, Pivac N, Jakovljević M, Muck Šeler D. The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia. Journal of Photochemistry and Photobiology B: Biology [Internet]. 2007 December [cited 2024 November 25];89(2-3):63-69. doi: 10.1016/j.jphotobiol.2007.09.002

Đ. Ljubičić, T. Stipčević, N. Pivac, M. Jakovljević and D. Muck Šeler, "The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia", Journal of Photochemistry and Photobiology B: Biology, vol. 89, no. 2-3, pp. 63-69, December 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:943708. [Accessed: 25 November 2024]

Metadata
Title (english)The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia
AuthorĐulijano Ljubičić
AuthorTamara Stipčević
AuthorNela Pivac
AuthorMiro Jakovljević
AuthorDorotea Muck-Šeler
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Platelet serotonin (5-HT) can be used as a limited, peripheral model for the central 5-HT synaptosomes. Altered platelet 5-HT concentrations have been associated with psychiatric disorders like depression and schizophrenia. The aim of the present study was to compare platelet 5-HT concentrations during long, medium and short period of natural daylight exposure in a large number of medication-free male and female schizophrenic and depressed patients and sex-matched healthy controls. Platelet 5-HT concentration was determined spectrofluorimetrically in 240 (97 female, 143 male) schizophrenic and 258 (153 female, 105 male) nonpsychotic, nonsuicidal depressed medication-free patients and 328 (149 women, 179 men) healthy subjects during periods with short (<12), long (>12) and medium (average 12) hours of the natural daylight. Platelet 5-HT concentration was significantly lower in women compared to men in all groups. Healthy male subjects had significantly higher (p=0.011) platelet 5-HT concentrations during long compared to medium period. There were no significant differences (p>0.05) in platelet 5-HT concentration between different periods in healthy women. The significant increase in platelet 5-HT values were found in female (p=0.01) and male (p=0.029) depressed patients during long compared to short period. There were no significant associations between platelet 5-HT concentrations and different periods in both male and female schizophrenic patients. The results indicate the sex-related differences in the serotonergic system. The alterations of platelet 5-HT concentrations, observed across period with different durations of daylight exposure, point to a direct or indirect effect of light on peripheral 5-HT system that could be related to different sensitivity of the pineal gland to light and/or melatonin influence on 5-HT metabolism.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Photochemistry and Photobiology B: Biology
Numberingvol. 89, no. 2-3, pp. 63-69
p-ISSN1011-1344
DOIhttps://doi.org/10.1016/j.jphotobiol.2007.09.002
URN:NBNurn:nbn:hr:105:943708
Publication2007-12
Document URLhttps://doi.org/10.1016/j.jphotobiol.2007.09.002
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:58:08