prikaz prve stranice dokumenta Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
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Scientific paper - Original scientific paper
Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
Translational Psychiatry, 8 (2018), 1; 150. https://doi.org/doi:10.1038/s41398-018-0198-3
Ren, Hongyan; Fabbri, Chiara; Uher, Rudolf; Rietschel, Marcella; Mors, Ole; Henigsberg, Neven; Hauser, Joanna; Zobel, Astrid; Maier, Wolfgang; Dernovsek, Mojca Z.; Souery, Daniel; Cattaneo, Annamaria; Breen, Gerome; Craig, Ian W.; Farmer, Anne E.; McGuffin, Peter; Lewis, Cathryn M.; Aitchison, Katherine J. More authors...

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Ren, H., Fabbri, C., Uher, R., Rietschel, M., Mors, O., Henigsberg, N. ... Aitchison, K. J. (2018). Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP). Translational Psychiatry, 8. (1), 150. doi: doi:10.1038/s41398-018-0198-3

Ren, Hongyan, et al. "Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)." Translational Psychiatry, vol. 8, no. 1, 2018, p. 150. https://doi.org/doi:10.1038/s41398-018-0198-3

Ren, Hongyan, Chiara Fabbri, Rudolf Uher, Marcella Rietschel, Ole Mors, Neven Henigsberg, Joanna Hauser, et al. "Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)." Translational Psychiatry 8, no. 1 (2018): 150. https://doi.org/doi:10.1038/s41398-018-0198-3

Ren, H., et al. (2018) 'Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)', Translational Psychiatry, 8(1), p. 150. doi: doi:10.1038/s41398-018-0198-3

Ren H, Fabbri C, Uher R, Rietschel M, Mors O, Henigsberg N, and sur.. Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP). Translational Psychiatry [Internet]. 2018 August 13 [cited 2024 May 26];8(1):150. doi: doi:10.1038/s41398-018-0198-3

H. Ren, et al., "Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)", Translational Psychiatry, vol. 8, no. 1, p. 150, August 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:522445. [Accessed: 26 May 2024]

Metadata
Title (english)Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
AuthorHongyan Ren
AuthorChiara Fabbri
AuthorRudolf Uher
AuthorMarcella Rietschel
AuthorOle Mors
AuthorNeven Henigsberg
AuthorJoanna Hauser
AuthorAstrid Zobel
AuthorWolfgang Maier
AuthorMojca Z. Dernovsek
AuthorDaniel Souery
AuthorAnnamaria Cattaneo
AuthorGerome Breen
AuthorIan W. Craig
AuthorAnne E. Farmer
AuthorPeter McGuffin
AuthorCathryn M. Lewis
AuthorKatherine J. Aitchison
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide association study (GWAS) followed by investigation of biological pathway enrichment using an anhedonia dimension for 759 patients with MDD in the GENDEP study. The GWAS identified 18 SNPs associated at genome-wide significance with the top one being an intronic SNP (rs9392549) in PRPF4B (pre-mRNA processing factor 4B) located on chromosome 6 (P = 2.07 × 10-9) while gene-set enrichment analysis returned one gene ontology term, axon cargo transport (GO: 0008088) with a nominally significant P value (1.15 × 10-5). Furthermore, our exploratory analysis yielded some interesting, albeit not statistically significant genetic correlation with Parkinson's Disease and nucleus accumbens gray matter. In addition, polygenic risk scores (PRSs) generated from our association analysis were found to be able to predict treatment efficacy of the antidepressants in this study. In conclusion, we found some markers significantly associated with anhedonia, and some suggestive findings of related pathways and biological functions, which could be further investigated in other studies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleTranslational Psychiatry
Numberingvol. 8, no. 1, p. 150
p-ISSN2158-3188
DOIhttps://doi.org/doi:10.1038/s41398-018-0198-3
URN:NBNurn:nbn:hr:105:522445
Publication2018-08-13
Document URLhttp://doi.org/10.1038/s41398-018-0198-3
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:01:18