prikaz prve stranice dokumenta The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
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Scientific paper - Original scientific paper
The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
Scientific Reports, 8 (2018), 1; 17873. https://doi.org/doi:10.1038/s41598-018-35903-5
Podrimaj-Bytyqi, Arjeta; Borovečki, Ana; Selimi, Qerim; Manxhuka-Kerliu, Suzana; Gashi, Goneta; Elezaj, Isa R.

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Podrimaj Bytyqi, A., Borovečki, A., Selimi, Q., Manxhuka Kerliu, S., Gashi, G. & Elezaj, I. R. (2018). The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma. Scientific Reports, 8. (1), 17873. doi: doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi, Arjeta, et al. "The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma." Scientific Reports, vol. 8, no. 1, 2018, p. 17873. https://doi.org/doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi, Arjeta, Ana Borovečki, Qerim Selimi, Suzana Manxhuka Kerliu, Goneta Gashi and Isa R. Elezaj. "The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma." Scientific Reports 8, no. 1 (2018): 17873. https://doi.org/doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi, A., et al. (2018) 'The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma', Scientific Reports, 8(1), p. 17873. doi: doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi A, Borovečki A, Selimi Q, Manxhuka Kerliu S, Gashi G, Elezaj IR. The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma. Scientific Reports [Internet]. 2018 December 14 [cited 2024 December 12];8(1):17873. doi: doi:10.1038/s41598-018-35903-5

A. Podrimaj Bytyqi, A. Borovečki, Q. Selimi, S. Manxhuka Kerliu, G. Gashi and I. R. Elezaj, "The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma", Scientific Reports, vol. 8, no. 1, p. 17873, December 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:266621. [Accessed: 12 December 2024]

Metadata
Title (english)The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
AuthorArjeta Podrimaj-Bytyqi
AuthorAna Borovečki
AuthorQerim Selimi
AuthorSuzana Manxhuka-Kerliu
AuthorGoneta Gashi
AuthorIsa R. Elezaj
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Bladder urothelial cell carcinoma (UCC) is an increasingly prevalent cancer worldwide, and thus, gaining a better understanding of its identifiable risk factors is a global priority. This study addressed this public health need with the understanding that cancer-initiating events, such as chromosome breakage, loss and rearrangement, can be reasonably used as biomarkers to evaluate an individual's cancer risk. Overall, forty bladder cancer patients and twenty controls were evaluated for genomic instability. To the best of the investigators' knowledge, this is the first study to perform micronucleus (MN) assays simultaneously in urothelial exfoliated cells (UEC), buccal exfoliated cells (BEC), and peripheral blood lymphocytes (PBL) in first-diagnosed, non-smoker bladder UCC patients. Additionally, the frequency of nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in PBL was evaluated. The MN frequencies in UEC, BEC, and PBL, as well as the frequencies of NPBs and NBUDs, were significantly higher in patients than in controls. In conclusion, MN assays, particularly in UEC, may be used to identify individuals who are at high risk of developing UCC, as single or as additional triage test to UroVysion FISH test. Our results further validate the efficacy of biomarkers, such as MN, NPBs, and NBUDs, as predictors of genomic instability.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 8, no. 1, p. 17873
p-ISSN2045-2322
DOIhttps://doi.org/doi:10.1038/s41598-018-35903-5
URN:NBNurn:nbn:hr:105:266621
Publication2018-12-14
Document URLhttp://doi.org/10.1038/s41598-018-35903-5
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:03:28