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Scientific paper - Original scientific paper
Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis
Frontiers in Psychiatry, 9 (2018); 488. https://doi.org/doi:10.3389/fpsyt.2018.00488
Rojnić Kuzman, Martina; Bošnjak Kuharić, Dina; Kekin, Ivana; Makarić, Porin; Madžarac, Zoran; Koričančić Makar, Ana; Kudlek Mikulić, Suzan; Bajić, Žarko; Bistrović, Petra; Bonacin, Dora; Vogrinc, Željka

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Rojnić Kuzman, M., Bošnjak Kuharić, D., Kekin, I., Makarić, P., Madžarac, Z., Koričančić Makar, A. ... Vogrinc, Ž. (2018). Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis. Frontiers in Psychiatry, 9., 488. doi: doi:10.3389/fpsyt.2018.00488

Rojnić Kuzman, Martina, et al. "Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis." Frontiers in Psychiatry, vol. 9, 2018, p. 488. https://doi.org/doi:10.3389/fpsyt.2018.00488

Rojnić Kuzman, Martina, Dina Bošnjak Kuharić, Ivana Kekin, Porin Makarić, Zoran Madžarac, Ana Koričančić Makar, Suzan Kudlek Mikulić, et al. "Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis." Frontiers in Psychiatry 9 (2018): 488. https://doi.org/doi:10.3389/fpsyt.2018.00488

Rojnić Kuzman, M., et al. (2018) 'Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis', Frontiers in Psychiatry, 9, p. 488. doi: doi:10.3389/fpsyt.2018.00488

Rojnić Kuzman M, Bošnjak Kuharić D, Kekin I, Makarić P, Madžarac Z, Koričančić Makar A, and sur.. Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis. Frontiers in Psychiatry [Internet]. 2018 October 16 [cited 2024 December 04];9:488. doi: doi:10.3389/fpsyt.2018.00488

M. Rojnić Kuzman, et al., "Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis", Frontiers in Psychiatry, vol. 9, p. 488, October 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:954623. [Accessed: 04 December 2024]

Metadata
Title (english)Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis
AuthorMartina Rojnić Kuzman
AuthorDina Bošnjak Kuharić
AuthorIvana Kekin
AuthorPorin Makarić
AuthorZoran Madžarac
AuthorAna Koričančić Makar
AuthorSuzan Kudlek Mikulić
AuthorŽarko Bajić
AuthorPetra Bistrović
AuthorDora Bonacin
AuthorŽeljka Vogrinc
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Antipsychotic-induced weight gain and metabolic abnormalities are one of the major challenges in the treatment of psychosis, contributing to the morbidity, mortality and treatment non-adherence. Different approaches were used to counteract these side effects but showed only limited or short-term effects. This study aims to analyse the effects of a long-term multimodal treatment program for first episode psychosis on antipsychotic-induced metabolic changes. ----- Methods: We enrolled 71 patients with first episode psychosis treated at the Zagreb University Hospital Centre from 2016 until 2018. Participants were assigned to one of the two groups: day hospital program vs. treatment as usual (TAU). Outcomes were: body weight, blood glucose, lipids and cholesterol, psychopathology and global level of functioning during the 18-months follow-up. ----- Results: Although the TAU group gained more weight and had higher increase of blood glucose, while the day hospital group had a higher increase in total cholesterol at 18th month follow-up, after the adjustment for age, gender and baseline measures, the type of treatment was not significantly associated with any of the primary outcome measures. Patients' psychopathology measures significantly decreased and their functional level significantly increased at month 18th in both groups. ----- Conclusion: While both types of treatment were effective in reducing psychopathology and restoring the patients' level of functioning, both were relatively ineffective in counteracting antipsychotic-induced metabolic abnormalities and antipsychotic-induced weight gain.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Psychiatry
Numberingvol. 9, p. 488
p-ISSN1664-0640
DOIhttps://doi.org/doi:10.3389/fpsyt.2018.00488
URN:NBNurn:nbn:hr:105:954623
Publication2018-10-16
Document URLhttp://doi.org/10.3389/fpsyt.2018.00488
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:04:10