prikaz prve stranice dokumenta Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection
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Scientific paper - Original scientific paper
Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection
Revista da Sociedade Brasileira de Medicina Tropical, 51 (2018), 5; 591-595. https://doi.org/doi:10.1590/0037-8682-0482-2017
Vilibić-Čavlek, Tatjana; Kristofić, Branimir; Savić, Vladimir; Kolarić, Branko; Barbić, Ljubo; Tabain, Irena; Perić, Ljiljana; Sabadi, Dario; Miklaušić, Bozana; Potočnik-Hunjadi, Tanja; Zember, Sanja; Stevanović, Vladimir; Listes, Eddy; Savini, Giovanni

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Vilibić Čavlek, T., Kristofić, B., Savić, V., Kolarić, B., Barbić, Lj., Tabain, I. ... Savini, G. (2018). Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection. Revista da Sociedade Brasileira de Medicina Tropical, 51. (5), 591-595. doi: doi:10.1590/0037-8682-0482-2017

Vilibić Čavlek, Tatjana, et al. "Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection." Revista da Sociedade Brasileira de Medicina Tropical, vol. 51, no. 5, 2018, pp. 591-595. https://doi.org/doi:10.1590/0037-8682-0482-2017

Vilibić Čavlek, Tatjana, Branimir Kristofić, Vladimir Savić, Branko Kolarić, Ljubo Barbić, Irena Tabain, Ljiljana Perić, et al. "Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection." Revista da Sociedade Brasileira de Medicina Tropical 51, no. 5 (2018): 591-595. https://doi.org/doi:10.1590/0037-8682-0482-2017

Vilibić Čavlek, T., et al. (2018) 'Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection', Revista da Sociedade Brasileira de Medicina Tropical, 51(5), pp. 591-595. doi: doi:10.1590/0037-8682-0482-2017

Vilibić Čavlek T, Kristofić B, Savić V, Kolarić B, Barbić Lj, Tabain I, and sur.. Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection. Revista da Sociedade Brasileira de Medicina Tropical [Internet]. 2018 November [cited 2024 November 23];51(5):591-595. doi: doi:10.1590/0037-8682-0482-2017

T. Vilibić Čavlek, et al., "Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection", Revista da Sociedade Brasileira de Medicina Tropical, vol. 51, no. 5, pp. 591-595, November 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:675021. [Accessed: 23 November 2024]

Metadata
Title (english)Diagnostic significance of immunoglobulin G avidity in symptomatic and asymptomatic West Nile virus infection
AuthorTatjana Vilibić-Čavlek
AuthorBranimir Kristofić
AuthorVladimir Savić
AuthorBranko Kolarić
AuthorLjubo Barbić
AuthorIrena Tabain
AuthorLjiljana Perić
AuthorDario Sabadi
AuthorBozana Miklaušić
AuthorTanja Potočnik-Hunjadi
AuthorSanja Zember
AuthorVladimir Stevanović
AuthorEddy Listes
AuthorGiovanni Savini
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
INTRODUCTION: West Nile virus (WNV) immunoglobulin M (IgM) antibodies have been shown to persist for up to 500 days in certain patients. To evaluate the usefulness of immunoglobulin G (IgG) avidity assessment in the diagnosis of WNV infection, we analyzed 54 WNV IgM- and/or IgG-positive serum samples from 39 patients with neuroinvasive disease and 15 asymptomatic cases tested during a seroprevalence investigation. ----- METHODS: Serological tests (WNV IgM/IgG antibody detection, IgG avidity) were performed using commercially available enzyme-linked immunosorbent assays. ----- RESULTS: WNV IgM antibodies were detected in 47 (87%) samples. Acute/recent WNV infection was confirmed based on low/borderline avidity index (AI) in 44 IgM-positive samples (93.6%). In three IgM-positive samples (6.4%), high IgG AIs were detected, thus indicating persisting IgM antibodies from previous infections. All IgM-negative samples showed high AIs. Patients with WNV neuroinvasive disease tested within 30 days showed low AIs. In six patients tested 34-50 days after disease onset, AI was borderline (42%-60%), suggesting earlier WNV IgG maturation. Samples with the highest IgM values were associated with the lowest AIs (Spearman's rho coefficient -0.767, p < 0.001). ----- CONCLUSIONS: Our results indicate that IgG avidity differentiates current/recent WNV infection from persistent IgM seropositivity from the previous WNV transmission season both in patients with WNV neuroinvasive disease and in asymptomatic persons. A strong negative correlation between IgM antibody levels and AI indicates that in cases with very high IgM levels, determination of IgG avidity may not be necessary. As many patients showed rapid avidity maturation, low IgG avidity is indicative of WNV infection within the previous month.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleRevista da Sociedade Brasileira de Medicina Tropical
Numberingvol. 51, no. 5, pp. 591-595
p-ISSN0037-8682
DOIhttps://doi.org/doi:10.1590/0037-8682-0482-2017
URN:NBNurn:nbn:hr:105:675021
Publication2018-11
Document URLhttp://doi.org/10.1590/0037-8682-0482-2017
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:05:11