prikaz prve stranice dokumenta Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina
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Scientific paper - Original scientific paper
Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina
Medicinski glasnik, 15 (2018), 1; 37-45. urn:nbn:hr:105:475901
Uzunović, Selma; Ibrahimagić, Amir; Bedenić, Branka

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Uzunović, S., Ibrahimagić, A. & Bedenić, B. (2018). Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina. Medicinski glasnik, 15. (1), 37-45. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:475901

Uzunović, Selma, et al. "Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina." Medicinski glasnik, vol. 15, no. 1, 2018, pp. 37-45. https://urn.nsk.hr/urn:nbn:hr:105:475901

Uzunović, Selma, Amir Ibrahimagić and Branka Bedenić. "Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina." Medicinski glasnik 15, no. 1 (2018): 37-45. https://urn.nsk.hr/urn:nbn:hr:105:475901

Uzunović, S., Ibrahimagić, A. and Bedenić, B. (2018) 'Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina', Medicinski glasnik, 15(1), pp. 37-45. Available at: https://urn.nsk.hr/urn:nbn:hr:105:475901 (Accessed 27 April 2024)

Uzunović S, Ibrahimagić A, Bedenić B. Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina. Medicinski glasnik [Internet]. 2018 February 01 [cited 2024 April 27];15(1):37-45. Available at: https://urn.nsk.hr/urn:nbn:hr:105:475901

S. Uzunović, A. Ibrahimagić and B. Bedenić, "Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina", Medicinski glasnik, vol. 15, no. 1, pp. 37-45, February 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:475901. [Accessed: 27 April 2024]

Metadata
Title (english)Antibiotic resistance in Enterobacter cloacae strains with derepressed/partly derepressed/inducible AmpC and extended spectrum beta-lactamases in Zenica-Doboj Canton, Bosnia and Herzegovina
AuthorSelma Uzunović
AuthorAmir Ibrahimagić
AuthorBranka Bedenić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To investigate the prevalence of derepressed/partly derepressed/inducible and ESBL/AmpC-producing Enterobacter cloacae isolates and treatment options for infections associated with those isolates. ----- METHODS: Antibiotic susceptibility was determined by disc diffusion and broth microdilution according to CLSI guidelines. Doubledisk synergy test (DDST) was performed in order to screen for ESBLs and combined disk test with phenylboronic acid to detect AmpC β -lactamases. PCR was used to detect blaESBL/blacarb genes. Genetic relatedness of the strains was determined by pulsed-fieldgel-electrophoresis (PFGE). ----- RESULTS: Among 14 isolates with the ESBL positive E. cloaceae producing isolates, four (28.6%), nine (64.3%) and one (7.1%) isolates were derepressed/partly derepressed and inducible AmpC producers. Eleven (out of 14) isolates were resistant to cefotaxime, ceftazidime, ceftriaxone, aminoglycosides and fluoroquinolones. All isolates were susceptible to imipenem and meropenem, 79% to cefepime. Five (out of 14; 35.7%) isolates (four derepressed and one inducible AmpC carrying E. cloaceae) were negative in phenotypic test for ESBLs, but positive for broad spectrum TEM-1 β-lactamase. One (out of four derepressed) also produced CMY-2 β-lactamase. Four (out of nine) partly derepressed isolates were positive with the DDST, but did not yield PCR products with primers targeting TEM, SHV and CTX-M beta-lactamases. Four positive partly derepressed isolates carried a blaCTX-M-1 gene, two blaOXA-1 one blaCTX-M-15, OXA-1 and one blaCTX-M-28, OXA-1 (n=1). ----- CONCLUSION: Microbiology laboratories must be able to detect and recognize AmpC-carrying isolates in a timely manner, especially those that are falsely susceptible in vitro to drugs that may be consideredfor therapy of infected patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicinski glasnik
Numberingvol. 15, no. 1, pp. 37-45
p-ISSN1840-0132
URN:NBNurn:nbn:hr:105:475901
Publication2018-02-01
Document URLhttp://ljkzedo.ba/sites/default/files/Glasnik/MG28/01%20Uzunovic%20925%20A.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:13:00