prikaz prve stranice dokumenta Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections
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Scientific paper - Original scientific paper
Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections
International Journal of Surgery, 54 (2018), Pt A; 248-253. https://doi.org/doi:10.1016/j.ijsu.2018.05.001
Rakić, Mislav; Patrlj, Leonardo; Amić, Fedor; Aralica, Gorana; Grgurević, Ivica

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Rakić, M., Patrlj, L., Amić, F., Aralica, G. & Grgurević, I. (2018). Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections. International Journal of Surgery, 54. (Pt A), 248-253. doi: doi:10.1016/j.ijsu.2018.05.001

Rakić, Mislav, et al. "Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections." International Journal of Surgery, vol. 54, no. Pt A, 2018, pp. 248-253. https://doi.org/doi:10.1016/j.ijsu.2018.05.001

Rakić, Mislav, Leonardo Patrlj, Fedor Amić, Gorana Aralica and Ivica Grgurević. "Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections." International Journal of Surgery 54, no. Pt A (2018): 248-253. https://doi.org/doi:10.1016/j.ijsu.2018.05.001

Rakić, M., et al. (2018) 'Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections', International Journal of Surgery, 54(Pt A), pp. 248-253. doi: doi:10.1016/j.ijsu.2018.05.001

Rakić M, Patrlj L, Amić F, Aralica G, Grgurević I. Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections. International Journal of Surgery [Internet]. 2018 June [cited 2024 May 05];54(Pt A):248-253. doi: doi:10.1016/j.ijsu.2018.05.001

M. Rakić, L. Patrlj, F. Amić, G. Aralica and I. Grgurević, "Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections", International Journal of Surgery, vol. 54, no. Pt A, pp. 248-253, June 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:565127. [Accessed: 05 May 2024]

Metadata
Title (english)Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections
AuthorMislav Rakić
AuthorLeonardo Patrlj
AuthorFedor Amić
AuthorGorana Aralica
AuthorIvica Grgurević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To compare and evaluate the hepatoprotective effect of remote ischemic preconditioning (RIPC) with local ischemic preconditioning (LIPC) of the liver during human liver resections. ----- METHODS: A prospective, single-centre, randomised control trial was conducted in the Clinical Hospital "***" from April 2017 to January 2018. A total of 60 patients, who underwent liver resection due to colorectal cancer liver metastasis, were randomised to one of three study arms: 1) a RIPC group, 2) an LIPC group and 3) a control group (CG) in which no ischemic preconditioning was done before liver resection. The hepatoprotective effect was evaluated by comparing serum transaminase levels, bilirubin levels, albumin, and protein levels, coagulograms and through pathohistological analysis. The trial was registered on ClinicalTrials.gov (NCT****). ----- RESULTS: Significant differences were found in serum levels of liver transaminases and bilirubin levels between the groups, the highest level in the CG and the lowest level in the LIPC group. Levels of cholinesterase were also significantly higher in the LIPC group. Pathohistological findings graded by the Rodriguez score showed favourable changes in the LIPC and RIPC groups versus the CG. ----- CONCLUSION: Strong evidence supports the hepatoprotective effect of RIPC and LIPC preconditioning from an ischemia-reperfusion injury of the liver. Better synthetic liver function preservation in these two groups supports this conclusion.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Journal of Surgery
Numberingvol. 54, no. Pt A, pp. 248-253
p-ISSN1743-9191
DOIhttps://doi.org/doi:10.1016/j.ijsu.2018.05.001
URN:NBNurn:nbn:hr:105:565127
Publication2018-06
Document URLhttp://doi.org/10.1016/j.ijsu.2018.05.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:18:10