prikaz prve stranice dokumenta Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia
  Download
PDF 1 MB
Scientific paper - Original scientific paper
Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia
Scientific Reports, 8 (2018), 1; 6113. https://doi.org/doi:10.1038/s41598-018-24446-4
Višković, Klaudija; Židovec Lepej, Snježana; Gorenec, Ana; Grgić, Ivana; Lukas, Davorka; Zekan, Šime; Dragobratović, Anja; Trupković, Maja; Begovac, Josip

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Višković, K., Židovec Lepej, S., Gorenec, A., Grgić, I., Lukas, D., Zekan, Š. ... Begovac, J. (2018). Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia. Scientific Reports, 8. (1), 6113. doi: doi:10.1038/s41598-018-24446-4

Višković, Klaudija, et al. "Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia." Scientific Reports, vol. 8, no. 1, 2018, p. 6113. https://doi.org/doi:10.1038/s41598-018-24446-4

Višković, Klaudija, Snježana Židovec Lepej, Ana Gorenec, Ivana Grgić, Davorka Lukas, Šime Zekan, Anja Dragobratović, Maja Trupković and Josip Begovac. "Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia." Scientific Reports 8, no. 1 (2018): 6113. https://doi.org/doi:10.1038/s41598-018-24446-4

Višković, K., et al. (2018) 'Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia', Scientific Reports, 8(1), p. 6113. doi: doi:10.1038/s41598-018-24446-4

Višković K, Židovec Lepej S, Gorenec A, Grgić I, Lukas D, Zekan Š, and sur.. Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia. Scientific Reports [Internet]. 2018 April 17 [cited 2025 January 18];8(1):6113. doi: doi:10.1038/s41598-018-24446-4

K. Višković, et al., "Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia", Scientific Reports, vol. 8, no. 1, p. 6113, April 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:982107. [Accessed: 18 January 2025]

Metadata
Title (english)Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia
AuthorKlaudija Višković
AuthorSnježana Židovec Lepej
AuthorAna Gorenec
AuthorIvana Grgić
AuthorDavorka Lukas
AuthorŠime Zekan
AuthorAnja Dragobratović
AuthorMaja Trupković
AuthorJosip Begovac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Patients successfully treated for HIV infection still have an increased risk for cardiovascular morbidity and mortality, which might be related not only to traditional risks, but also to inflammation and dyslipidemia. We examined the relationship of serum lipid levels with plasma biomarkers of inflammation using a composite inflammatory burden score (IBS) based on individual (>75th percentile) measurements from the following seven markers: CD40L, tPA, MCP-1, IL-8, IL-6, hCRP and P-selectin. IBS was categorized as 0 (none of the biomarkers >75th percentile), 1, 2 and 3 or more scores. Correlations between the IBS and lipid parameters were examined by ordered logistic regression proportional odds models to estimate the odds of more elevated biomarkers. 181 male patients with undetectable HIV-viremia were included into the study. In the multivariate model, a one-unit increase (mmol/L) of total cholesterol and triglycerides was associated with a 1.41-fold (95% CI, 1.13-1.76) and 1.37-fold (95% CI, 1.18-1.60) increased odds of having a greater IBS, respectively. Those with an IBS score ≥1 compared to none had 2.14 (95% CI, 1.43-3.20) higher odds of having a one-unit increased total cholesterol/HDL-cholesterol ratio. In successfully treated HIV-infected persons dyslipidemia was associated with inflammation.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 8, no. 1, p. 6113
p-ISSN2045-2322
DOIhttps://doi.org/doi:10.1038/s41598-018-24446-4
URN:NBNurn:nbn:hr:105:982107
Publication2018-04-17
Document URLhttp://doi.org/10.1038/s41598-018-24446-4
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:19:02