prikaz prve stranice dokumenta Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology
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Scientific paper - Original scientific paper
Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology
Contact Dermatitis, 76 (2017), 5; 287-295. https://doi.org/10.1111/cod.12770
Koppes, Sjors A.; Ljubojević Hadžavdić, Suzana; Jakasa, Ivone; Franceschi, Nika; Riethmüller, Christoph; Jurakić Tončic, Ružica; Marinović, Branka; Raj, Nidhin; Rawlings, Anthony V.; Voegeli, Rainer; Lane, Majella E.; Haftek, Marek; Frings-Dresen, Monique H.W.; Rustemeyer, Thomas; Kezic, Sanja More authors...

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Koppes, S. A., Ljubojević Hadžavdić, S., Jakasa, I., Franceschi, N., Riethmüller, C., Jurakić Tončic, R. ... Kezic, S. (2017). Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology. Contact Dermatitis, 76. (5), 287-295. doi: 10.1111/cod.12770

Koppes, Sjors A., et al. "Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology." Contact Dermatitis, vol. 76, no. 5, 2017, pp. 287-295. https://doi.org/10.1111/cod.12770

Koppes, Sjors A., Suzana Ljubojević Hadžavdić, Ivone Jakasa, Nika Franceschi, Christoph Riethmüller, Ružica Jurakić Tončic, Branka Marinović, et al. "Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology." Contact Dermatitis 76, no. 5 (2017): 287-295. https://doi.org/10.1111/cod.12770

Koppes, S. A., et al. (2017) 'Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology', Contact Dermatitis, 76(5), pp. 287-295. doi: 10.1111/cod.12770

Koppes SA, Ljubojević Hadžavdić S, Jakasa I, Franceschi N, Riethmüller C, Jurakić Tončic R, and sur.. Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology. Contact Dermatitis [Internet]. 2017 May [cited 2024 May 19];76(5):287-295. doi: 10.1111/cod.12770

S. A. Koppes, et al., "Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology", Contact Dermatitis, vol. 76, no. 5, pp. 287-295, May 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:349615. [Accessed: 19 May 2024]

Metadata
Title (english)Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology
AuthorSjors A. Koppes
AuthorSuzana Ljubojević Hadžavdić
AuthorIvone Jakasa
AuthorNika Franceschi
AuthorChristoph Riethmüller
AuthorRužica Jurakić Tončic
AuthorBranka Marinović
AuthorNidhin Raj
AuthorAnthony V. Rawlings
AuthorRainer Voegeli
AuthorMajella E. Lane
AuthorMarek Haftek
AuthorMonique H.W. Frings-Dresen
AuthorThomas Rustemeyer
AuthorSanja Kezic
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography. ----- OBJECTIVE: To explore this phenomenon in allergic contact dermatitis. ----- METHODS: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine. Moreover, a control (pet.) patch and an irritant (SLS) patch were applied. After 3 days, the stratum corneum from tested sites was collected, and NMF levels and corneocyte morphology, expressed as the amount of circular nanosize objects, quantified according to the Dermal Texture Index (DTI), were determined. ----- RESULTS: Among allergens, only MCI/MI reduced NMF levels significantly, as did SLS. Furthermore, only MCI/MI caused remarkable changes at the microscopic level; the corneocytes were hexagonal-shaped with pronounced cell borders and a smoother surface. The DTI was increased after SLS exposure but not after allergen exposure. ----- CONCLUSIONS: MCI/MI significantly decreased NMF levels, similarly to SLS. The altered corneocyte morphology suggests that skin barrier damage plays a role in the pathogenesis of MCI/MI contact allergy. The DTI seems to differentiate reactions to SLS from those to the allergens tested, as SLS was the only agent that caused a DTI increase.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleContact Dermatitis
Numberingvol. 76, no. 5, pp. 287-295
p-ISSN0105-1873
DOIhttps://doi.org/10.1111/cod.12770
URN:NBNurn:nbn:hr:105:349615
Publication2017-05
Document URLhttps://doi.org/10.1111/cod.12770
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:21:30