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master's thesis
Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:808761
Vrtar, Izabela
University of Zagreb
School of Medicine
Department of Medical Microbiology and Parasitology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Vrtar, I. (2015). Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:808761

Vrtar, Izabela. "Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:808761

Vrtar, Izabela. "Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:808761

Vrtar, I. (2015). 'Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske', Master's thesis, University of Zagreb, School of Medicine, accessed 28 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:808761

Vrtar I. Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 April 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:808761

I. Vrtar, "Epidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:808761

Metadata
TitleEpidemiološke značajke infekcije uzrokovane citomegalovirusom na području Hrvatske
Title (english)Epidemiological characteristics of cytomegalovirus infection in Croatia
AuthorIzabela Vrtar
MentorGodrana Mlinarić-Galinović (mentor)
Committee memberSven Seiwerth (predsjednik povjerenstva)
Committee memberGoran Tešović (član povjerenstva)
Committee memberGodrana Mlinarić-Galinović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Epidemiology
Abstract
Citomegalovirus (CMV) je virus rasprostranjen diljem svijeta. Prevalencija se razlikuje u različitim područjima i različitim populacijskim skupinama. Cilj ovog istraživanja bio je analizirati seroprevalenciju i epidemiološke značajke CMV infekcije u Hrvatskoj. U istraživanju je sudjelovalo 1446 ispitanika testiranih tijekom dvogodišnjeg razdoblja (2013-2014. godine). Ispitivanu je skupinu sačinjavalo 537 (37%) muškaraca i 909 (63%) žena u dobi od 2 mjeseca do 84 godine. CMV IgM i IgG protutijela dokazana su pomoću komercijalnog imunoenzimnog testa. U svih IgM/IgG reaktivnih uzoraka određen je aviditet IgG protutijela za potvrdu akutne primarne CMV infekcije. CMV IgG protutijela dokazana su u ukupno 74% ispitanika. Seroprevalencija se nije značajno razlikovala između muškaraca (72%) i žena (75%). Uočen je značajan porast seropozitiviteta s dobi. U djece mlađe od 6 mjeseci nađena je visoka seroprevalencija (79%), što je ukazivalo na transplacentarno prenesena majčina protutijela. Nakon 6 mjeseci, CMV seroprevalencija je postupno rasla s 48% u dobnoj skupini od 6 mjeseci do 9 godina do 93% u ispitanika starijih od 60 godina (p <0,001). Seroprevalencija se nije razlikovala između stanovnika urbanih područja (74%) u odnosu na one iz prigradskih/ruralnih područja (72%). Uspoređujući različite populacijske skupine, prevalencija CMV IgG protutijela je bila najniža (54%) u djece i adolescenata, 77% u odrasloj općoj populaciji te vrlo visoka u bolesnika na hemodijalizi (92 %; p < 0,001 ). Akutna infekcija dokazana je u 4% bolesnika (u 52% dokazana je akutna primarna CMV infekcija na temelju niskog IgG aviditeta, dok je u 48% visok aviditet ukazivao na CMV reaktivaciju ili reinfekciju). Većina primarnih infekcija (86%) je zabilježena je kod osoba mlađih od 30 godina. Nasuprot tome, CMV reaktivacija/reinfekcija se javljala u svim dobnim skupinama s učestalošću od 5% do 25%, počevši s dobnom skupinom od 20 do 29 godina. U trudnica nije bilo razlike u IgG ili IgM seropozitivnosti između žena s urednom i žena s patološkom trudnoćom.
Abstract (english)
Cytomegalovirus (CMV) is a ubiquitous virus throughout the world. The prevalence of antibodies varies in different regions and different population groups. The aim of this study was to analyze the seroprevalence and epidemiological characteristics of CMV infection in Croatia. The study included 1446 Croatian inhabitants tested during a two-year period (2013-2014). There were 537 (37%) males and 909 (63%) males and females aged 2 months to 84 years. CMV IgM and IgG antibodies were detected using a commercial ELISA test. All IgM/IgG reactive samples were further tested for IgM avidity to confirm acute primary CMV infection. The overall CMV IgG seroprevalence rate was 74%. There were no significant differences in the seropositivity among males (72%) and females (75%). A significant increase in the seroprevalence with age was observed. In children less than 6 months, a high positivity was found (79%) which indicate transplacentally derived maternal antibodies. After 6 months, CMV seropositivity progressively increased from 48% in 6 months-9-years age group to 93% in participants above 60 (p<0.001). Seroprevalence did not differ among participants residing in urban areas (74%) compared to those residing in suburban/rural areas (72%). Comparing different population groups, seropositivity was lowest (54%) in children and adolescents, 77% in adult general population and very high in patients on hemodialysis (92%; p<0,001). Acute infection was detected in 4% patients (in 52% acute primary CMV infection was documented by low IgG avidity while in 48% high AI indicates CMV reactivation or reinfection). The majority of primary infections (86%) were detected in subjects less than 30 years. In contrast, CMV reactivation/reinfection was common in all age groups (5-25%) starting with 20-29 age group. In pregnant women there was no difference in the IgG or IgM seropositivity among women with normal pregnancy and women with bad obstetric history.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:808761
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-08-12 07:29:31