prikaz prve stranice dokumenta Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype
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Scientific paper - Original scientific paper
Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype
Clinical Neurophysiology, 129 (2018), 8; 1588-1594. https://doi.org/10.1016/j.clinph.2018.05.009
Adamec, Ivan; Crnošija, Luka; Junaković, Anamari; Krbot Skorić, Magdalena; Habek, Mario

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Adamec, I., Crnošija, L., Junaković, A., Krbot Skorić, M. & Habek, M. (2018). Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype. Clinical Neurophysiology, 129. (8), 1588-1594. doi: 10.1016/j.clinph.2018.05.009

Adamec, Ivan, et al. "Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype." Clinical Neurophysiology, vol. 129, no. 8, 2018, pp. 1588-1594. https://doi.org/10.1016/j.clinph.2018.05.009

Adamec, Ivan, Luka Crnošija, Anamari Junaković, Magdalena Krbot Skorić and Mario Habek. "Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype." Clinical Neurophysiology 129, no. 8 (2018): 1588-1594. https://doi.org/10.1016/j.clinph.2018.05.009

Adamec, I., et al. (2018) 'Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype', Clinical Neurophysiology, 129(8), pp. 1588-1594. doi: 10.1016/j.clinph.2018.05.009

Adamec I, Crnošija L, Junaković A, Krbot Skorić M, Habek M. Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype. Clinical Neurophysiology [Internet]. 2018 August [cited 2024 April 29];129(8):1588-1594. doi: 10.1016/j.clinph.2018.05.009

I. Adamec, L. Crnošija, A. Junaković, M. Krbot Skorić and M. Habek, "Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype", Clinical Neurophysiology, vol. 129, no. 8, pp. 1588-1594, August 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:819302. [Accessed: 29 April 2024]

Metadata
Title (english)Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype
AuthorIvan Adamec
AuthorLuka Crnošija
AuthorAnamari Junaković
AuthorMagdalena Krbot Skorić
AuthorMario Habek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVE: To determine autonomic dysfunction (AD) differences in patients with relapsing remitting multiple sclerosis (pwRRMS) and progressive MS (pwPMS). ----- METHODS: Composite autonomic scoring scale (CASS) and heart rate variability (HRV) were performed in 40 pwRRMS and 30 pwPMS. ----- RESULTS: pwPMS had a significantly higher sudomotor index and total CASS score compared to pwRRMS (p < 0.001 and p < 0.001, respectively). Disease duration positively correlated with sudomotor index and total CASS (rs = 0.409, p < 0.001 and rs = 0.472, p < 0.001, respectively), while the Expanded Disability Status Scale (EDSS) positively correlated with sudomotor index and total CASS (rs = 0.411, p < 0.001 and rs = 0.402, p = 0.001, respectively) in all patients. Type of multiple sclerosis (pwRRMS or pwPMS) corrected for age, sex and disease duration, was a statistically significant predictor of CASS value (B = 1.215, p = 0.019). Compared to pwRRMS, pwPMS had a significantly lower standard deviation of NN intervals (SDNN), low frequency (LF), and high frequency (HF), during both the supine and tilt-up phases (all p-values <0.006). pwPMS had a significantly lower LF/HF (p = 0.008) during tilt-up. ----- CONCLUSION: There is a significant difference in autonomic function in pwRRMS and pwPMS; with pwPMS having a higher burden of AD, which is particularly evident for sweating dysfunction. ----- SIGNIFICANCE: Further research is needed to establish whether parasympathetic and sudomotor dysfunction may serve as markers of progressive MS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleClinical Neurophysiology
Numberingvol. 129, no. 8, pp. 1588-1594
p-ISSN1388-2457
DOIhttps://doi.org/10.1016/j.clinph.2018.05.009
URN:NBNurn:nbn:hr:105:819302
Publication2018-08
Document URLhttp://doi.org/10.1016/j.clinph.2018.05.009
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:25:44