prikaz prve stranice dokumenta Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria
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Scientific paper - Original scientific paper
Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria
Multiple Sclerosis and Related Disorders, 25 (2018); 99-103. https://doi.org/10.1016/j.msard.2018.07.035
Habek, Mario; Pavičić, Tin; Ruška, Berislav; Pavlović, Ivan; Gabelić, Tereza; Barun, Barbara; Adamec, Ivan; Crnošija, Luka; Krbot Skorić, Magdalena

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Habek, M., Pavičić, T., Ruška, B., Pavlović, I., Gabelić, T., Barun, B. ... Krbot Skorić, M. (2018). Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria. Multiple Sclerosis and Related Disorders, 25., 99-103. doi: 10.1016/j.msard.2018.07.035

Habek, Mario, et al. "Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria." Multiple Sclerosis and Related Disorders, vol. 25, 2018, pp. 99-103. https://doi.org/10.1016/j.msard.2018.07.035

Habek, Mario, Tin Pavičić, Berislav Ruška, Ivan Pavlović, Tereza Gabelić, Barbara Barun, Ivan Adamec, Luka Crnošija and Magdalena Krbot Skorić. "Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria." Multiple Sclerosis and Related Disorders 25 (2018): 99-103. https://doi.org/10.1016/j.msard.2018.07.035

Habek, M., et al. (2018) 'Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria', Multiple Sclerosis and Related Disorders, 25, pp. 99-103. doi: 10.1016/j.msard.2018.07.035

Habek M, Pavičić T, Ruška B, Pavlović I, Gabelić T, Barun B, and sur.. Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria. Multiple Sclerosis and Related Disorders [Internet]. 2018 October [cited 2024 December 27];25:99-103. doi: 10.1016/j.msard.2018.07.035

M. Habek, et al., "Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria", Multiple Sclerosis and Related Disorders, vol. 25, pp. 99-103, October 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:262218. [Accessed: 27 December 2024]

Metadata
Title (english)Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria
AuthorMario Habek
AuthorTin Pavičić
AuthorBerislav Ruška
AuthorIvan Pavlović
AuthorTereza Gabelić
AuthorBarbara Barun
AuthorIvan Adamec
AuthorLuka Crnošija
AuthorMagdalena Krbot Skorić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To compare the sensitivity, specificity and accuracy of the 2010 and 2017 revisions of the McDonald criteria in a Croatian cohort of patients with a clinically isolated syndrome (CIS). ----- METHODS: Prospectively collected data from 113 patients were retrospectively analyzed. Sensitivity, specificity and accuracy for both criteria were calculated regarding conversion to clinically definite multiple sclerosis (Poser CDMS) or multiple sclerosis (MS) (defined as fulfilment of clinical or MRI evidence for dissemination in space and the development of a second relapse and/or ≥1 new T2 lesions on the follow-up MRIs) during a two-year follow-up. Survival analysis was performed to estimate the cumulative risk of patients developing Poser CDMS. Binary logistic regression model was used to determine which variables are statistically significant predictors for the conversion to MS. ----- RESULTS: The 2017 revision had higher sensitivity (85 vs. 30% and 85 vs. 41%) and lower specificity (33 vs. 63% and 63 vs. 85%) compared to the 2010 revisions, for conversion to Poser CDMS and MS, respectively. Patients who did not meet the 2017 McDonald criteria had a higher chance of conversion-free survival for Poser CDMS than those who met the 2017 McDonald criteria (p = 0.037). Results of the multivariate regression analysis revealed that patients who at baseline fulfilled 2017 revisions of the McDonald criteria have the increased likelihood of conversion to MS (Exp(B) 9.68, 95%CI 3.62-25.90, p < 0.00001). ----- CONCLUSION: This study provides new information about the application of the 2017 revisions of the McDonald criteria in a Croatian cohort of patients with typical CIS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMultiple Sclerosis and Related Disorders
Numberingvol. 25, pp. 99-103
p-ISSN2211-0348
DOIhttps://doi.org/10.1016/j.msard.2018.07.035
URN:NBNurn:nbn:hr:105:262218
Publication2018-10
Document URLhttp://doi.org/10.1016/j.msard.2018.07.035
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:26:43