prikaz prve stranice dokumenta HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival
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Scientific paper - Original scientific paper
HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival
PLoS One, 14 (2019), 2; https://doi.org/10.1371/journal.pone.0211577
Božinović, Ksenija; Sabol, Ivan; Rakušić, Zoran; Jakovčević, Antonia; Šekerija, Mario; Lukinović, Juraj; Prgomet, Drago; Grce, Magdalena

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Božinović, K., Sabol, I., Rakušić, Z., Jakovčević, A., Šekerija, M., Lukinović, J. ... Grce, M. (2019). HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival. PLoS One, 14. (2). doi: 10.1371/journal.pone.0211577

Božinović, Ksenija, et al. "HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival." PLoS One, vol. 14, no. 2, 2019. https://doi.org/10.1371/journal.pone.0211577

Božinović, Ksenija, Ivan Sabol, Zoran Rakušić, Antonia Jakovčević, Mario Šekerija, Juraj Lukinović, Drago Prgomet and Magdalena Grce. "HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival." PLoS One 14, no. 2 (2019). https://doi.org/10.1371/journal.pone.0211577

Božinović, K., et al. (2019) 'HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival', PLoS One, 14(2). doi: 10.1371/journal.pone.0211577

Božinović K, Sabol I, Rakušić Z, Jakovčević A, Šekerija M, Lukinović J, and sur.. HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival. PLoS One [Internet]. 2019 February 01 [cited 2024 April 28];14(2). doi: 10.1371/journal.pone.0211577

K. Božinović, et al., "HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival", PLoS One, vol. 14, no. 2, February 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:414795. [Accessed: 28 April 2024]

Metadata
Title (english)HPV-driven oropharyngeal squamous cell cancer in Croatia — demography and survival
AuthorKsenija Božinović
AuthorIvan Sabol
AuthorZoran Rakušić
AuthorAntonia Jakovčević
AuthorMario Šekerija
AuthorJuraj Lukinović
AuthorDrago Prgomet
AuthorMagdalena Grce
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objectives: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Main HNSCC risk factors are tobacco, alcohol, and high-risk human papillomavirus (HPV). HPV+ oropharyngeal squamous cell cancer (OPSCC) usually have different etiology, increasing incidence and often show an improved survival when compared to HPV-negative cases. The objective of the current study was to retrospectively examine the influence of HPV on the survival of OPSCC patients in a non-Western population setting. ----- Materials and methods: We determined the presence of HPV DNA and/or RNA in 99 formalin-fixed paraffin embedded (FFPE) tissue samples of OPSCC patients treated between 2002 and 2015. Patients were compared based on laboratory, demographic, clinical, life style characteristics and survival. ----- Results: HPV RNA was found in 29.3% cases. However, groups based on HPV data (either RNA, DNA or retrospectively collected p16 staining) did not show significant differences. Overall, 5-year survival was 30% with minimal influence of the HPV positivity. ----- Conclusions: The HPV influence on survival of OPSCC patients is not identical between populations probably due to other factors overshadowing the HPV effect. This should be taken into account when treatment or policy decisions are made in each particular setting.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS One
Numberingvol. 14, no. 2
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0211577
URN:NBNurn:nbn:hr:105:414795
Publication2019-02-01
Document URLhttp://doi.org/10.1371/journal.pone.0211577
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:28:34