prikaz prve stranice dokumenta In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms
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Scientific paper - Original scientific paper
In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms
Journal of Infection and Chemotherapy, 24 (2018), 12; 1016-1019. https://doi.org/10.1016/j.jiac.2018.06.001
Bedenić, Branka; Car, Haris; Slačanac, Domagoj; Sviben, Mario; Čačić, Marko; Lukić-Grlić, Amarela; Benčić, Ana; Šijak, Dorotea; Tripković, Marko; Beader, Nataša

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Bedenić, B., Car, H., Slačanac, D., Sviben, M., Čačić, M., Lukić Grlić, A. ... Beader, N. (2018). In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms. Journal of Infection and Chemotherapy, 24. (12), 1016-1019. doi: 10.1016/j.jiac.2018.06.001

Bedenić, Branka, et al. "In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms." Journal of Infection and Chemotherapy, vol. 24, no. 12, 2018, pp. 1016-1019. https://doi.org/10.1016/j.jiac.2018.06.001

Bedenić, Branka, Haris Car, Domagoj Slačanac, Mario Sviben, Marko Čačić, Amarela Lukić Grlić, Ana Benčić, Dorotea Šijak, Marko Tripković and Nataša Beader. "In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms." Journal of Infection and Chemotherapy 24, no. 12 (2018): 1016-1019. https://doi.org/10.1016/j.jiac.2018.06.001

Bedenić, B., et al. (2018) 'In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms', Journal of Infection and Chemotherapy, 24(12), pp. 1016-1019. doi: 10.1016/j.jiac.2018.06.001

Bedenić B, Car H, Slačanac D, Sviben M, Čačić M, Lukić Grlić A, and sur.. In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms. Journal of Infection and Chemotherapy [Internet]. 2018 December [cited 2024 April 28];24(12):1016-1019. doi: 10.1016/j.jiac.2018.06.001

B. Bedenić, et al., "In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms", Journal of Infection and Chemotherapy, vol. 24, no. 12, pp. 1016-1019, December 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513120. [Accessed: 28 April 2024]

Metadata
Title (english)In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms
AuthorBranka Bedenić
AuthorHaris Car
AuthorDomagoj Slačanac
AuthorMario Sviben
AuthorMarko Čačić
AuthorAmarela Lukić-Grlić
AuthorAna Benčić
AuthorDorotea Šijak
AuthorMarko Tripković
AuthorNataša Beader
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases; combinations of two metallo-β-lactamases (MBL) or MBL with OXA-48. Colistin-resistant strain positive for OXA-48 was also included in the study. ----- Methods: The antibiotic susceptibility was tested by broth microdilution method. Synergy was tested by chequerboard, time-kill and 2-well method. PAE was determined by viable counting. ----- Results: The chequerboard analysis revealed synergy for colistin combination with meropenem in all isolates with FICI values ranging from 0.12 to 0.24. FICI values for combinations with vancomycin were below 0.5 indicating synergy in two out of four isolates. K. pneumoniae 609815 positive for OXA-48 and colistin resistant showed the most pronounced and consistent synergy effect with meropenem in both chequerboard and time-kill method. Synergy effect in time-kill curves, was observed for K pneumoniae 145846 with two MBLs and colistin resistant K. pneumoniae 609815 positive for OXA-48, with both combinations including meropenem and vancomycin. Colistin alone exhibited short postantibiotic effect (PAE) against all tested isolates. Meropenem markedly prolonged the PAE in two isolates in contrast to vancomycin which did not demonstrate significant effect on the duration of PAE. ----- Conclusions: The synergy effect and the duration of PAE was strain and antibiotic dependent but not related to the resistance gene content.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Infection and Chemotherapy
Numberingvol. 24, no. 12, pp. 1016-1019
p-ISSN1341-321X
DOIhttps://doi.org/10.1016/j.jiac.2018.06.001
URN:NBNurn:nbn:hr:105:513120
Publication2018-12
Document URLhttp://doi.org/10.1016/j.jiac.2018.06.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:30:35