prikaz prve stranice dokumenta Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis
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Scientific paper - Original scientific paper
Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis
Acta Neurologica Scandinavica, 115 (2007), 2; 109-114. https://doi.org/10.1111/j.1600-0404.2006.00726.x
Židovec Lepej, Snježana; Mišić-Majerus, Ljiljana; Jeren, Tatjana; Đaković Rode, Oktavija; Remenar, Anica; Šporec, Vesna; Vince, Adriana

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Židovec Lepej, S., Mišić Majerus, Lj., Jeren, T., Đaković Rode, O., Remenar, A., Šporec, V. & Vince, A. (2007). Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis. Acta Neurologica Scandinavica, 115. (2), 109-114. doi: 10.1111/j.1600-0404.2006.00726.x

Židovec Lepej, Snježana, et al. "Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis." Acta Neurologica Scandinavica, vol. 115, no. 2, 2007, pp. 109-114. https://doi.org/10.1111/j.1600-0404.2006.00726.x

Židovec Lepej, Snježana, Ljiljana Mišić Majerus, Tatjana Jeren, Oktavija Đaković Rode, Anica Remenar, Vesna Šporec and Adriana Vince. "Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis." Acta Neurologica Scandinavica 115, no. 2 (2007): 109-114. https://doi.org/10.1111/j.1600-0404.2006.00726.x

Židovec Lepej, S., et al. (2007) 'Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis', Acta Neurologica Scandinavica, 115(2), pp. 109-114. doi: 10.1111/j.1600-0404.2006.00726.x

Židovec Lepej S, Mišić Majerus Lj, Jeren T, Đaković Rode O, Remenar A, Šporec V, and sur.. Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis. Acta Neurologica Scandinavica [Internet]. 2007 February [cited 2024 May 04];115(2):109-114. doi: 10.1111/j.1600-0404.2006.00726.x

S. Židovec Lepej, et al., "Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis", Acta Neurologica Scandinavica, vol. 115, no. 2, pp. 109-114, February 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:384164. [Accessed: 04 May 2024]

Metadata
Title (english)Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis
AuthorSnježana Židovec Lepej
AuthorLjiljana Mišić-Majerus
AuthorTatjana Jeren
AuthorOktavija Đaković Rode
AuthorAnica Remenar
AuthorVesna Šporec
AuthorAdriana Vince
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: The aim of our study was to determine whether cerebrospinal fluid (CSF) of patients with tick-borne encephalitis (TBE) contains CXCL10, CXCL11, p40 subunit of interleukin-12 (IL-12)/IL-23, IL-18 and IL-15. We compared serum and CSF concentrations of CXCL10 and analysed the possible concentration gradient of this chemokine between the periphery and central nervous system. ----- MATERIALS AND METHODS: The study enrolled 19 TBE patients and 10 patients with non-inflammatory neurological diseases. ----- RESULTS: CSF of TBE patients contained CXCL10 (median 217 pg/ml), CXCL11 (8.3 pg/ml), p40 subunit of IL-12/IL-23 (38.9 pg/ml), IL-18 (30.1 pg/ml) and IL-15 (5.9 pg/ml). CXCL10 in the CSF of TBE patients was higher compared with serum (median 62 pg/ml, P < 0.001). ----- CONCLUSION: CSF of TBE patients contains CXCL10, CXCL11, p40 subunit of IL-12/IL-23, IL-18 and IL-15. Increased CXCL10 concentration in CSF suggests a role for this chemokine in the recruitment of CXCR3-expressing T-cells into the CSF of TBE patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleActa Neurologica Scandinavica
Numberingvol. 115, no. 2, pp. 109-114
p-ISSN0001-6314
DOIhttps://doi.org/10.1111/j.1600-0404.2006.00726.x
URN:NBNurn:nbn:hr:105:384164
Publication2007-02
Document URLhttps://doi.org/10.1111/j.1600-0404.2006.00726.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:31:47