prikaz prve stranice dokumenta Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients
  Download
PDF 226.11 KB
Scientific paper - Original scientific paper
Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients
Clinical Chemistry and Laboratory Medicine, 57 (2019), 11; 1799-1804. https://doi.org/10.1515/cclm-2019-0037
Degoricija, Vesna; Trbušić, Matias; Potočnjak, Ines; Radulović, Bojana; Pregartner, Gudrun; Berghold, Andrea; Scharnagl, Hubert; Stojaković, Tatjana; Tiran, Beate; Frank, Saša

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Degoricija, V., Trbušić, M., Potočnjak, I., Radulović, B., Pregartner, G., Berghold, A. ... Frank, S. (2019). Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients. Clinical Chemistry and Laboratory Medicine, 57. (11), 1799-1804. doi: 10.1515/cclm-2019-0037

Degoricija, Vesna, et al. "Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients." Clinical Chemistry and Laboratory Medicine, vol. 57, no. 11, 2019, pp. 1799-1804. https://doi.org/10.1515/cclm-2019-0037

Degoricija, Vesna, Matias Trbušić, Ines Potočnjak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Hubert Scharnagl, Tatjana Stojaković, Beate Tiran and Saša Frank. "Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients." Clinical Chemistry and Laboratory Medicine 57, no. 11 (2019): 1799-1804. https://doi.org/10.1515/cclm-2019-0037

Degoricija, V., et al. (2019) 'Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients', Clinical Chemistry and Laboratory Medicine, 57(11), pp. 1799-1804. doi: 10.1515/cclm-2019-0037

Degoricija V, Trbušić M, Potočnjak I, Radulović B, Pregartner G, Berghold A, and sur.. Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients. Clinical Chemistry and Laboratory Medicine [Internet]. 2019 October 29 [cited 2024 November 04];57(11):1799-1804. doi: 10.1515/cclm-2019-0037

V. Degoricija, et al., "Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients", Clinical Chemistry and Laboratory Medicine, vol. 57, no. 11, pp. 1799-1804, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:046298. [Accessed: 04 November 2024]

Metadata
Title (english)Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients
AuthorVesna Degoricija
AuthorMatias Trbušić
AuthorInes Potočnjak
AuthorBojana Radulović
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorHubert Scharnagl
AuthorTatjana Stojaković
AuthorBeate Tiran
AuthorSaša Frank
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Plasma free fatty acids (FFA) are higher in heart failure (HF) patients compared to healthy controls. Considering that the extent of FFA elevation in HF might mirror the severity of HF, we hypothesized that the serum levels of FFA may be a useful prognostic indicator for 3-month mortality in acute heart failure (AHF). ----- Methods: We analyzed the serum samples of AHF patients obtained at admission to the emergency department. Serum levels of FFA were analyzed using an enzymatic reagent on an automatic analyzer. ----- Results: Out of 152 included AHF patients that were originally included, serum samples of 132 patients were available for the quantification of FFA. Of these, 35 (26.5%) died within 3 months of onset of AHF. These patients had significantly higher serum levels of FFA compared to AHF patients who were alive 3 months after onset of AHF. Univariable logistic regression analyses showed a significant positive association of FFA levels with 3-month mortality (odds ratio [OR] 2.76 [95% confidence interval 1.32-6.27], p = 0.010). Importantly, this association remained significant after adjusting for age and sex, as well as for further clinical and laboratory parameters that showed a significant association with 3-month mortality in the univariate analyses. ----- Conclusions: We conclude that the admission serum levels of FFA are associated with 3-month mortality in AHF patients. Therefore, measurements of circulating FFA levels may help identifying high-risk AHF patients.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinical Chemistry and Laboratory Medicine
Numberingvol. 57, no. 11, pp. 1799-1804
p-ISSN1434-6621
DOIhttps://doi.org/10.1515/cclm-2019-0037
URN:NBNurn:nbn:hr:105:046298
Publication2019-10-29
Document URLhttp://doi.org/10.1515/cclm-2019-0037
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:32:07