prikaz prve stranice dokumenta Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients
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Scientific paper - Original scientific paper
Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients
Scientific Reports, 9 (2019), 1; https://doi.org/10.1038/s41598-019-42937-w
Stryeck, Sarah; Gastrager, Michaela; Degoricija, Vesna; Trbušić, Matias; Potočnjak, Ines; Radulović, Bojana; Pregartner, Gudrun; Berghold, Andrea; Madl, Tobias; Frank, Saša

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Stryeck, S., Gastrager, M., Degoricija, V., Trbušić, M., Potočnjak, I., Radulović, B. ... Frank, S. (2019). Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients. Scientific Reports, 9. (1). doi: 10.1038/s41598-019-42937-w

Stryeck, Sarah, et al. "Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients." Scientific Reports, vol. 9, no. 1, 2019. https://doi.org/10.1038/s41598-019-42937-w

Stryeck, Sarah, Michaela Gastrager, Vesna Degoricija, Matias Trbušić, Ines Potočnjak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Tobias Madl and Saša Frank. "Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients." Scientific Reports 9, no. 1 (2019). https://doi.org/10.1038/s41598-019-42937-w

Stryeck, S., et al. (2019) 'Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients', Scientific Reports, 9(1). doi: 10.1038/s41598-019-42937-w

Stryeck S, Gastrager M, Degoricija V, Trbušić M, Potočnjak I, Radulović B, and sur.. Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients. Scientific Reports [Internet]. 2019 May 01 [cited 2024 May 04];9(1). doi: 10.1038/s41598-019-42937-w

S. Stryeck, et al., "Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients", Scientific Reports, vol. 9, no. 1, May 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:475691. [Accessed: 04 May 2024]

Metadata
Title (english)Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients
AuthorSarah Stryeck
AuthorMichaela Gastrager
AuthorVesna Degoricija
AuthorMatias Trbušić
AuthorInes Potočnjak
AuthorBojana Radulović
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorTobias Madl
AuthorSaša Frank
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Considering the already established relationship between the extent of the metabolic dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic profile of the serum may have a prognostic capacity for 3-month mortality in acute heart failure (AHF). Out of 152 recruited patients, 130 serum samples were subjected to the metabolomic analyses. The 3-month mortality rate was 24.6% (32 patients). Metabolomic profiling by nuclear magnetic resonance spectroscopy found that the serum levels of 2-hydroxybutyrate (2-HB), 3-hydoxybutyrate (3-HB), lactate, citrate, and tyrosine, were higher in patients who died within 3 months compared to those who were alive 3 months after onset of AHF, which was confirmed by univariable logistic regression analyses (p = 0.009, p = 0.005, p = 0.008, p<0.001, and p<0.001, respectively). These associations still remained significant for all tested metabolites except for lactate after adjusting for established prognostic parameters in HF. In conclusion, serum levels of 2-HB, 3-HB, tyrosine, and citrate measured at admission are associated with an increased 3-month mortality rate in AHF patients and might thus be of prognostic value in AHF.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 9, no. 1
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-019-42937-w
URN:NBNurn:nbn:hr:105:475691
Publication2019-05-01
Document URLhttp://doi.org/10.1038/s41598-019-42937-w
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:33:56