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master's thesis
Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:618857
Rora, Mia
University of Zagreb
School of Medicine
Department of Anatomy and Clinical Anatomy

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Rora, M. (2015). Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:618857

Rora, Mia. "Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:618857

Rora, Mia. "Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:618857

Rora, M. (2015). 'Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora', Master's thesis, University of Zagreb, School of Medicine, accessed 02 May 2024, https://urn.nsk.hr/urn:nbn:hr:105:618857

Rora M. Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 May 02] Available at: https://urn.nsk.hr/urn:nbn:hr:105:618857

M. Rora, "Utjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:618857

Metadata
TitleUtjecaj povišene i snižene razine perifernog serotonina na trabekularnu koštanu masu štakora
Title (english)The influence of raised and reduced levels of peripheral serotonin on trabecular bone mass in rats
AuthorMia Rora
MentorSlobodan Vukičević (mentor)
Committee memberLovorka Grgurević (predsjednik povjerenstva)
Committee memberZdravko Petanjek (član povjerenstva)
Committee memberSlobodan Vukičević (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract
U nedavnim istraţivanjima se pokazalo kako periferni serotonin djeluje inhibitorno na proces koštane formacije. U našem istraţivanju smo koristili sublinije ţivotinja dobivene selektivnim kriţanjem sa višom odnosno niţom razinom perifernog serotonina što predstavlja fiziološki model za razliku od modela s izbaĉenim genom u kojem su dobivene ekstremne vrijednosti. Kako bi pokazali utjecaj perifernog i centralnog serotonina analizirali smo distalni dio bedrene kosti i kraljeţnicu mikro CT-om te denzitometrijom. PotvrĊene su statistiĉki znaĉajne razlike relevantnih koštanih parametara ţivotinja sa sniţenom razinom serotonina u odnosu na ţivotinje sa povišenom razinom serotonina. Porastom vrijednosti serotonina dolazi do sniţavanja trabekularnog koštanog volumena. Nadalje, ţivotinje sa povišenom razinom serotonina imale su veću duljinu bedrene i goljeniĉne kosti od ţivotinja sa sniţenom razinom serotonina. Dobiveni rezultati mogli bi posluţiti u daljnjim istraţivanjima i razvoju nove anaboliĉke terapije kojoj bi mehanizam djelovanja bio inhibicija kljuĉnih dijelova serotoninskog puta.
Abstract (english)
Recent studies have shown that peripheral serotonin has an inhibitory effect on the process of bone formation. In our research, we used sublines of animals that have developed, through selective cross-breeding higher and lower levels of peripheral serotonin, which represents a physiological model, as opposed to the model with the excluded gene in which extreme values were obtained. To show the effect of peripheral and central serotonin, we have analysed the distal femur and the spine using micro-CT and densitometry. We confirmed statistically significant differences in relevant bone parameters of animals with reduced levels of serotonin, compared to animals with raised levels. The increase in the serotonin value leads to lowering trabecular bone volume. Measuring length and width of femur and shin bone we have found that increasing serotonin values leads to increasing bone length and width compared to animals with reduced levels of serotonin. The acquired results could help further research and the development of a new anabolic therapy, whose mechanism of action would be the inhibition of key parts of serotonergic pathways.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:618857
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-08-12 08:30:48