prikaz prve stranice dokumenta Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units
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Scientific paper - Original scientific paper
Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units
Journal of Clinical Medicine, 8 (2019), 10; https://doi.org/10.3390/jcm8101742
Jamialahmadi, Tannaz; Panahi, Yunes; Safarpour, Mohamamd Amin; Ganjali, Shiva; Chahabi, Mahdi; Reiner, Željko; Solgi, Saeed; Vahedian-azimi, Amir; Kianpour, Parisa; Banach, Maciej; Sahebkar, Amirhossein

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Jamialahmadi, T., Panahi, Y., Safarpour, M. A., Ganjali, S., Chahabi, M., Reiner, Ž. ... Sahebkar, A. (2019). Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units. Journal of Clinical Medicine, 8. (10). doi: 10.3390/jcm8101742

Jamialahmadi, Tannaz, et al. "Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units." Journal of Clinical Medicine, vol. 8, no. 10, 2019. https://doi.org/10.3390/jcm8101742

Jamialahmadi, Tannaz, Yunes Panahi, Mohamamd Amin Safarpour, Shiva Ganjali, Mahdi Chahabi, Željko Reiner, Saeed Solgi, et al. "Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units." Journal of Clinical Medicine 8, no. 10 (2019). https://doi.org/10.3390/jcm8101742

Jamialahmadi, T., et al. (2019) 'Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units', Journal of Clinical Medicine, 8(10). doi: 10.3390/jcm8101742

Jamialahmadi T, Panahi Y, Safarpour MA, Ganjali S, Chahabi M, Reiner Ž, and sur.. Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units. Journal of Clinical Medicine [Internet]. 2019 October 20 [cited 2024 December 25];8(10). doi: 10.3390/jcm8101742

T. Jamialahmadi, et al., "Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units", Journal of Clinical Medicine, vol. 8, no. 10, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:530663. [Accessed: 25 December 2024]

Metadata
Title (english)Association of serum PCSK9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units
AuthorTannaz Jamialahmadi
AuthorYunes Panahi
AuthorMohamamd Amin Safarpour
AuthorShiva Ganjali
AuthorMahdi Chahabi
AuthorŽeljko Reiner
AuthorSaeed Solgi
AuthorAmir Vahedian-azimi
AuthorParisa Kianpour
AuthorMaciej Banach
AuthorAmirhossein Sahebkar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Background: The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients with bacterial infections in intensive care units, the aim of this study was to investigate whether any such associations exist. ----- Methods: 100 patients (46 males, mean age 67.12 ± 1.34 years) with bacterial infections who were staying in an intensive care unit (ICU) longer than 48 h but less than 7 days and who were not receiving corticosteroids were analyzed. Their serum levels of albumin, C-reactive protein, glucose, lactate, blood urea nitrogen, prothrombin (international normalized ratio), total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, PCSK9, and procalcitonin were measured. The severity of the patients' condition was assessed by using the Glasgow Coma Scale (GCS), the Sequential Organ Failure Assessment (SOFA), and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scales. ----- Results: Using a hierarchical regression modeling approach, no significant association was found between PCSK9 levels and either the severity of disease (APACHE II, SOFA, and GCS) indices or resistance to antibiotics. ----- Conclusion: The results suggest that there is no association between PCSK9 levels and resistance to antibiotics or the condition of patients hospitalized in intensive care units.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 8, no. 10
p-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm8101742
URN:NBNurn:nbn:hr:105:530663
Publication2019-10-20
Document URLhttp://doi.org/10.3390/jcm8101742
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:36:49