prikaz prve stranice dokumenta Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study
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Scientific paper - Original scientific paper
Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study
Croatian Medical Journal, 49 (2008), 2; 207-214. https://doi.org/10.3325/cmj.2008.2.215
Francetić, Igor; Kalenić, Smilja; Huić, Mirjana; Merčep, Iveta; Makar-Aušperger, Ksenija; Likić, Robert; Erdeljić, Viktorija; Tripković, Vesna; Šimić, Petra

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Francetić, I., Kalenić, S., Huić, M., Merčep, I., Makar Aušperger, K., Likić, R. ... Šimić, P. (2008). Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study. Croatian Medical Journal, 49. (2), 207-214. doi: 10.3325/cmj.2008.2.215

Francetić, Igor, et al. "Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study." Croatian Medical Journal, vol. 49, no. 2, 2008, pp. 207-214. https://doi.org/10.3325/cmj.2008.2.215

Francetić, Igor, Smilja Kalenić, Mirjana Huić, Iveta Merčep, Ksenija Makar Aušperger, Robert Likić, Viktorija Erdeljić, Vesna Tripković and Petra Šimić. "Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study." Croatian Medical Journal 49, no. 2 (2008): 207-214. https://doi.org/10.3325/cmj.2008.2.215

Francetić, I., et al. (2008) 'Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study', Croatian Medical Journal, 49(2), pp. 207-214. doi: 10.3325/cmj.2008.2.215

Francetić I, Kalenić S, Huić M, Merčep I, Makar Aušperger K, Likić R, and sur.. Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study. Croatian Medical Journal [Internet]. 2008 April [cited 2025 January 08];49(2):207-214. doi: 10.3325/cmj.2008.2.215

I. Francetić, et al., "Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study", Croatian Medical Journal, vol. 49, no. 2, pp. 207-214, April 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:741076. [Accessed: 08 January 2025]

Metadata
Title (english)Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study
AuthorIgor Francetić
AuthorSmilja Kalenić
AuthorMirjana Huić
AuthorIveta Merčep
AuthorKsenija Makar-Aušperger
AuthorRobert Likić
AuthorViktorija Erdeljić
AuthorVesna Tripković
AuthorPetra Šimić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To determine the effect of aminoglycoside cycling in six tertiary intensive care units (ICU) on the rates of sepsis, aminoglycoside resistance patterns, antibiotic consumption, and costs. ----- METHODS: This was a prospective longitudinal interventional study that measured the effect of change from first-line gentamicin usage (February 2002-February 2003) to amikacin usage (February 2003-February 2004) on the aminoglycoside resistance patterns, number of patients with gram-negative bacteremia, consumption of antibiotics, and the cost of antimicrobial drugs in 6 tertiary care ICUs in Zagreb, Croatia. ----- RESULTS: The change from first-line gentamicin to amikacin usage led to a decrease in the overall gentamicin resistance of gram-negative bacteria (GNB) from 42% to 26% (P<0.001; z-test of proportions) and netilmicin resistance from 33% to 20% (P<0.001), but amikacin resistance did not change significantly (P=0.462), except for Acinetobacter baumanni (P=0.014). Sepsis rate in ICUs was reduced from 3.6% to 2.2% (P<0.001; chi(2) test), with a decline in the number of nosocomial bloodstream infections from 55/100 patient-days to 26/100 patient-days (P=0.001, chi(2) test). Furthermore, amikacin use led to a 16% decrease in the overall antibiotic consumption and 0.1 euro/patient/d cost reduction. ----- CONCLUSION: Exclusive use of amikacin significantly reduced the resistance of GNB isolates to gentamicin and netilmicin, the number of GNB nosocomial bacteremias, and the cost of total antibiotic usage in ICUs.
Abstract (croatian)
CILJ: Analizirati utjecaj ciklične primjene aminoglikozida u 6 tercijarnih odjela intenzivne skrbi na stopu pojave sepse, obrazac otpornosti na aminoglikozide, potrošnju antibiotika i troškove. ----- POSTUPCI: Ova prospektivna longitudinalna intervencijska studija mjerila je utjecaj prelaska s uporabe gentamicina (veljača 2002-veljača 2003) na amikacin (veljača 2003-veljača 2004) na obrazac otpornosti na aminoglikozide, broj bolesnika s gram-negativnom bakteremijom, potrošnju antibiotika, i trošak antimikrobnih lijekova na 6 tercijarnih odjela intenzivne skrbi u Zagrebu, Hrvatska. ----- REZULTATI: Prelazak s uporabe gentamicina na amikacin je doveo do pada ukupne otpornosti na gentamicin gram-negativnih bakterija (GNB) sa 42% na 26% (P<0,001; z-test proporcija) i otpornosti na netilmicin s 33% na 20% (P<0,001), ali se otpornost na amikacin nije značajano promijenila (P=0.462), osim kod Acinetobacter baumanni (P=0,014). Stopa pojave sepse na odjelu intezivne skrbi je smanjena s 3,6% na 2,2% (P<0,001; χ2 test), uz smanjenje broja bolničkih krvnih infekcija s 55/100 bolesničkih dana na 26/100 bolesničkih dana (P=0,001, χ2 test). Uporaba amikacina dovela je do 16-postotnog smanjenja u ukupnoj potrošnji antibiotika i smanjenju troškova za € 0,1 po pacijentu po danu. ----- ZALJUČAK: Uporaba amikacina značajno je smanjila otpornost GNB izolata na gentamicin i netilmicin, broj GNB bolničkih bakteremija, i troškove potrošnje antibiotika na odjelima intenzivne skrbi.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 49, no. 2, pp. 207-214
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2008.2.215
URN:NBNurn:nbn:hr:105:741076
Publication2008-04
Document URLhttp://www.cmj.hr/2008/49/2/18461676.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:43:42