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Scientific paper - Original scientific paper
Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia
Collegium Antropologicum, 32 (2008), Suppl.; 31-36. urn:nbn:hr:105:793183
Boban, Marina; Grbić, Kristina; Mladinov, Mihovil; Hof, Patrick R.; Süßmair, Christine; Ackl, Nibal; Stanić, Gabrijela; Bader, Benedikt; Danek, Adrian; Šimić, Goran

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Boban, M., Grbić, K., Mladinov, M., Hof, P. R., Süßmair, C., Ackl, N. ... Šimić, G. (2008). Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia. Collegium Antropologicum, 32. (Suppl.), 31-36. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:793183

Boban, Marina, et al. "Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia." Collegium Antropologicum, vol. 32, no. Suppl., 2008, pp. 31-36. https://urn.nsk.hr/urn:nbn:hr:105:793183

Boban, Marina, Kristina Grbić, Mihovil Mladinov, Patrick R. Hof, Christine Süßmair, Nibal Ackl, Gabrijela Stanić, Benedikt Bader, Adrian Danek and Goran Šimić. "Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia." Collegium Antropologicum 32, no. Suppl. (2008): 31-36. https://urn.nsk.hr/urn:nbn:hr:105:793183

Boban, M., et al. (2008) 'Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia', Collegium Antropologicum, 32(Suppl.), pp. 31-36. Available at: https://urn.nsk.hr/urn:nbn:hr:105:793183 (Accessed 07 November 2024)

Boban M, Grbić K, Mladinov M, Hof PR, Süßmair C, Ackl N, and sur.. Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia. Collegium Antropologicum [Internet]. 2008 January [cited 2024 November 07];32(Suppl.):31-36. Available at: https://urn.nsk.hr/urn:nbn:hr:105:793183

M. Boban, et al., "Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia", Collegium Antropologicum, vol. 32, no. Suppl., pp. 31-36, January 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:793183. [Accessed: 07 November 2024]

Metadata
Title (english)Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia
AuthorMarina Boban
AuthorKristina Grbić
AuthorMihovil Mladinov
AuthorPatrick R. Hof
AuthorChristine Süßmair
AuthorNibal Ackl
AuthorGabrijela Stanić
AuthorBenedikt Bader
AuthorAdrian Danek
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common causes of dementia in old people. They remain difficult to differentiate in practice because of lack of sensitivity and specificity of current clinical diagnostic criteria. Recent molecular and cellular advancements indicate that the use of cerebrospinal fluid markers may improve early detection and differential diagnosis of AD. Our objective in this study was to determine diagnostic accuracy of three cerebrospinal (CSF) markers: total tau protein (t-tau), tau protein phosphorylated on threonine 181 (p-tau181) and tau protein phosphorylated on serine 199 (p-tau199). Using commercially available ELISA kits concentrations of t-tau, p-tau181 and p-tau199 were analyzed in 12 patients with probable AD, 9 patients with VaD and 12 NC subjects. The median levels of all three markers were significantly higher in AD group versus VaD and NC groups. However, when the sensitivity levels were set to 85% or higher, only t-tau and p-tau199 satisfied consensus recommendations (specificity more than 75%) when differentiating AD from VaD. In conclusion, our preliminary data on a small group of selected subjects suggest that the CSF t-tau and p-tau199 levels are useful markers for differentiating AD from VaD.
Abstract (croatian)
Alzheimerova bolest (AD) i vaskularna demencija (VaD) dva su najčešća uzroka demencije u starih ljudi. Uslijed nedostatka osjetljivosti i specifičnosti kliničkih dijagnostičkih kriterija ova se dva poremećaja još uvijek teško razlikuju u praksi. Novija saznanja iz područja molekularne i stanične biologije ukazuju da bi korištenje markera iz cerebrospinalne tekućine (CSF) moglo unaprijediti ranu detekciju i diferencijalnu dijagnozu AD. Naš je cilj u ovom istraživanju bio odrediti dijagnostičku preciznost triju markera iz CSF: ukupnog tau proteina (t-tau), tau proteina fosforiliranog na treoninu 181 (p-tau 181) i tau proteina fosforiliranog na serinu 199 (p-tau199). Upotrebom komercijalno dostupnih ELISA kitova, analizirali smo razine t-tau, p-tau181 i p-tau199 u 12 pacijenata s dijagnozom vjerojatne AD, 9 pacijenata s VaD i 12 normalnih kontrola (NC). Medijane vrijednosti razina svih triju markera bile su značajno više u skupini pacijenata s vjerojatnom AD u odnosu na VaD i NC. Ipak, kada je prilikom diferenciranja AD od VaD razina osjetljivosti postavljena na 85% ili više, samo su t-tau i p-tau199 zadovoljili međunarodno usuglašene preporučene vrijednosti (specifičnost veću od 75%). Zaključno, naši preliminarni podaci na manjoj grupi odabranih ispitanika ukazuju da su t-tau i p-tau199 iz CSF korisni markeri za rano diferenciranje AD od VaD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. Suppl., pp. 31-36
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:793183
Publication2008-01
Document URLhttps://hrcak.srce.hr/24550
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:43:33