prikaz prve stranice dokumenta The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients
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Scientific paper - Original scientific paper
The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients
Collegium Antropologicum, 32 (2008), 1; 93-98. urn:nbn:hr:105:678879
Tomić, Monika; Galešić, Krešimir; Morović-Vergles, Jadranka; Romić, Željko; Mikulić, Ivanka

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Tomić, M., Galešić, K., Morović Vergles, J., Romić, Ž. & Mikulić, I. (2008). The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients. Collegium Antropologicum, 32. (1), 93-98. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:678879

Tomić, Monika, et al. "The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients." Collegium Antropologicum, vol. 32, no. 1, 2008, pp. 93-98. https://urn.nsk.hr/urn:nbn:hr:105:678879

Tomić, Monika, Krešimir Galešić, Jadranka Morović Vergles, Željko Romić and Ivanka Mikulić. "The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients." Collegium Antropologicum 32, no. 1 (2008): 93-98. https://urn.nsk.hr/urn:nbn:hr:105:678879

Tomić, M., et al. (2008) 'The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients', Collegium Antropologicum, 32(1), pp. 93-98. Available at: https://urn.nsk.hr/urn:nbn:hr:105:678879 (Accessed 06 May 2024)

Tomić M, Galešić K, Morović Vergles J, Romić Ž, Mikulić I. The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients. Collegium Antropologicum [Internet]. 2008 March [cited 2024 May 06];32(1):93-98. Available at: https://urn.nsk.hr/urn:nbn:hr:105:678879

M. Tomić, K. Galešić, J. Morović Vergles, Ž. Romić and I. Mikulić, "The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients", Collegium Antropologicum, vol. 32, no. 1, pp. 93-98, March 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:678879. [Accessed: 06 May 2024]

Metadata
Title (english)The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients
AuthorMonika Tomić
AuthorKrešimir Galešić
AuthorJadranka Morović-Vergles
AuthorŽeljko Romić
AuthorIvanka Mikulić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 (ET-1) and nitric oxide (NO) has been postulated, their concentrations were determined in plasma and urine of diabetic patients. The study included 30 diabetic patients (both IDDM and NIDDM) with initial or advanced diabetic nephropathy (decreased endogenous creatinine clearance, proteinuria) and 20 healthy control subjects. The correlation with blood pressure and other renal function parameters was monitored and compared with the control group. Also, the effect of ACE inhibitors (ACEI) on ET-1 and NO patterns was monitored in correlation with arterial hypertension. In diabetic patients that did not receive ACEI therapy, the increase in plasma ET-1 was associated with both systolic and diastolic blood pressure elevation, whereas in those administered ACEI the increase in plasma ET-1 was associated with a systolic blood pressure decline. In addition, the increase in plasma NO was accompanied by a statistically significant decline of both systolic and diastolic blood pressure in diabetic patients receiving ACEI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 1, pp. 93-98
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:678879
Publication2008-03
Document URLhttps://hrcak.srce.hr/22819
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:46:35