prikaz prve stranice dokumenta Serum gangliosides in patients with brain tumors
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Scientific paper - Original scientific paper
Serum gangliosides in patients with brain tumors
Collegium Antropologicum, 32 (2008), S. 1; 171-175. urn:nbn:hr:105:953694
Radić, Borislav; Vukelić, Željka; Kalanj Bognar, Svjetlana

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Radić, B., Vukelić, Ž. & Kalanj Bognar, S. (2008). Serum gangliosides in patients with brain tumors. Collegium Antropologicum, 32. (S. 1), 171-175. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:953694

Radić, Borislav, et al. "Serum gangliosides in patients with brain tumors." Collegium Antropologicum, vol. 32, no. S. 1, 2008, pp. 171-175. https://urn.nsk.hr/urn:nbn:hr:105:953694

Radić, Borislav, Željka Vukelić and Svjetlana Kalanj Bognar. "Serum gangliosides in patients with brain tumors." Collegium Antropologicum 32, no. S. 1 (2008): 171-175. https://urn.nsk.hr/urn:nbn:hr:105:953694

Radić, B., Vukelić, Ž. and Kalanj Bognar, S. (2008) 'Serum gangliosides in patients with brain tumors', Collegium Antropologicum, 32(S. 1), pp. 171-175. Available at: https://urn.nsk.hr/urn:nbn:hr:105:953694 (Accessed 04 May 2024)

Radić B, Vukelić Ž, Kalanj Bognar S. Serum gangliosides in patients with brain tumors. Collegium Antropologicum [Internet]. 2008 January [cited 2024 May 04];32(S. 1):171-175. Available at: https://urn.nsk.hr/urn:nbn:hr:105:953694

B. Radić, Ž. Vukelić and S. Kalanj Bognar, "Serum gangliosides in patients with brain tumors", Collegium Antropologicum, vol. 32, no. S. 1, pp. 171-175, January 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:953694. [Accessed: 04 May 2024]

Metadata
Title (english)Serum gangliosides in patients with brain tumors
AuthorBorislav Radić
AuthorŽeljka Vukelić
AuthorSvjetlana Kalanj Bognar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In order to determine possible differences in serum gangliosides content and composition before and after surgical removal of tumor, gangliosides isolated from preoperative and postoperative sera of patients with brain tumors were analyzed. Serum samples were collected from patients with glioblastoma, meningioma, acoustic neurinoma, haemangioma, oligodendroglioma and astrocytoma, one week before and one week after surgical removal of the tumor. Serum gangliosides were qualitatively and quantitatively analyzed by high performance thin layer chromatography and laser densitometry. Results showed changes of total gangliosides concentrations in analyzed postoperative sera comparing to preoperative sera. There was not a significant difference in ganglioside pattern of preoperative vs. preoperative sera. However, a postoperative decreased proportion of ganglioside GD3 was observed in sera derived from patients with complete tumor removal. The results of this study indicate that comparative quantitative and compositional analysis of both preoperative and postoperative serum gangliosides may provide useful information concerning tumor progression, surgical success and prognosis.
Abstract (croatian)
U ovom radu analizirani su gangliozidi izolirani iz preoperativnih i postoperativnih seruma pacijenata s moždanim tumorima, kako bi se utvrdile moguće razlike u sadržaju i sastavu serumskih gangliozida prije i poslije kirurškog odstranjenja tumora. Uzorci seruma sakupljeni su od pacijenata s dijagnozom glioblastoma, meningeoma, neurinoma, hemangioma, oligodendroglioma i astrocitoma, jedan tjedan prije i jedan tjedan nakon kirurškog uklanjanja tumora. Kvalitativna i kvantitativna analiza serumskih gangliozida provedena je tankoslojnom kromatografijom visoke moći razlučivanja i laserskom denzitometrijom. Rezultati su pokazali razlike ukupnih koncentracija gangliozida u analiziranim postoperativnim serumima u usporedbi s preoperativnim serumima. Gangliozidni obrazac preoperativnih i postoperativnih seruma nije se značajno razlikovao. Međutim, uočeno je postoperativno smanjenje udjela gangliozida GD3 u serumima pacijenata u kojih je tumor potpuno uklonjen. Rezultati ovog istraživanja ukazuju da poredbena kvantitativno-kvalitativna analiza preoperativnih i postoperativnih serumskih gangliozida može pružiti korisne podatke o tumorskoj progresiji, uspješnosti kirurškog postupka i prognozi.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. S. 1, pp. 171-175
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:953694
Publication2008-01
Document URLhttps://hrcak.srce.hr/24460
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:46:16