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Scientific paper - Original scientific paper
Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal
Collegium Antropologicum, 32 (2008), S. 1; 133-137. urn:nbn:hr:105:127589
Orešković, Darko; Maraković, Jurica; Vukić, Miroslav; Radoš, Milan; Klarica, Marijan

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Orešković, D., Maraković, J., Vukić, M., Radoš, M. & Klarica, M. (2008). Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal. Collegium Antropologicum, 32. (S. 1), 133-137. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:127589

Orešković, Darko, et al. "Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal." Collegium Antropologicum, vol. 32, no. S. 1, 2008, pp. 133-137. https://urn.nsk.hr/urn:nbn:hr:105:127589

Orešković, Darko, Jurica Maraković, Miroslav Vukić, Milan Radoš and Marijan Klarica. "Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal." Collegium Antropologicum 32, no. S. 1 (2008): 133-137. https://urn.nsk.hr/urn:nbn:hr:105:127589

Orešković, D., et al. (2008) 'Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal', Collegium Antropologicum, 32(S. 1), pp. 133-137. Available at: https://urn.nsk.hr/urn:nbn:hr:105:127589 (Accessed 30 December 2024)

Orešković D, Maraković J, Vukić M, Radoš M, Klarica M. Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal. Collegium Antropologicum [Internet]. 2008 January [cited 2024 December 30];32(S. 1):133-137. Available at: https://urn.nsk.hr/urn:nbn:hr:105:127589

D. Orešković, J. Maraković, M. Vukić, M. Radoš and M. Klarica, "Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal", Collegium Antropologicum, vol. 32, no. S. 1, pp. 133-137, January 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:127589. [Accessed: 30 December 2024]

Metadata
Title (english)Fluid perfusion as a method of cerebrospinal fluid formation rate - critical appraisal
AuthorDarko Orešković
AuthorJurica Maraković
AuthorMiroslav Vukić
AuthorMilan Radoš
AuthorMarijan Klarica
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The aim of the study was to evaluate whether or not cerebrospinal fluid formation rate (Vf) calculated according to the equation of Heisey et al., truly show the produced cerebrospinal fluid. For this reason Vf was simulated (40.6 microL/min) by an infusion pump in a plastic cylinder and the evaluation was done by comparing the results obtained between the calculated Vf and the simulated one. In both cases the result should be the same (40.6 micro/min). Other types of experiments were carried out by ventriculocisternal perfusion (92.4 microL/min) on anaesthetized and sacrificed cats. If the equation is correct, the calculated Vf for sacrificed animals should be zero, because there is no Vf in dead animals. The fact that the calculated Vf (46.5 microL/min) in the plastic cylinder was different (p < 0.0001) from the simulated one (40.6 microL/min) and that Vf was calculated even for dead animals (3-5 microL/min) clearly shows the that perfusion method may not be an accurate method for determination of Vf.
Abstract (croatian)
Svrha prikazanih istraživanja bila je provjeriti da li perfuziona metoda izračunavanja stvaranja cerebrospinalnog likvora (Vf) po Heiseyu i sur. zaista prikazuje stvaranje likvora. U tu svrhu »Vf« je u plastičnoj komorici simuliran pomoću infuzione pumpe (40,6 mL/min), a provjera je vršena uspoređivanjem rezultata izračunanog Vf-a s pomoću Heiseyeve perfuzione metode i onog simuliranog s pomoću pumpe. U slučaju da je prefusiona metoda točna, rezultat bi trebao biti u oba slučaja isti (40,6 mL/min). U drugoj skupini pokusa vršena je ventrikulocisternalna perfuzija (brzina 92,4 mL/min) na anesteziranim i žrtvovanim mačkama. Ukoliko je ispitivana perfuziona metoda točna izračunane vrijednosti na žrtvovanim mačkama Vf-a bi morale iznositi 0 mL/min, jer ne postoji stvaranje likvora na mrtvim životinjama. Budući da se izračunani »Vf« (46,5 mL/min) u plastičnoj komorici značajno razlikuje (p<0.0001) od simuliranog s pomoću pumpe (40,6 mL/min) i budući da je izračunani Vf kod mrtvih životinja varirao od 3–5 mL/min, onda to jasno ukazuje da se perfuziona metoda ne može koristiti kao pouzdana metoda za izračunavanje stvaranja cerebrospinalnog likvora (Vf).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. S. 1, pp. 133-137
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:127589
Publication2008-01
Document URLhttps://hrcak.srce.hr/24567
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:47:21