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Scientific paper - Original scientific paper
Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features
Collegium Antropologicum, 32 (2008), S. 1; 119-122. urn:nbn:hr:105:688163
Mimica, Ninoslav; Mück-Šeler, Dorotea; Pivac, Nela; Mustapić, Maja; Deželjin, Martina; Stipčević, Tamara; Presečki, Paola; Radonić, Elizabeta; Folnegović-Šmalc, Vera

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Mimica, N., Mück Šeler, D., Pivac, N., Mustapić, M., Deželjin, M., Stipčević, T. ... Folnegović Šmalc, V. (2008). Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features. Collegium Antropologicum, 32. (S. 1), 119-122. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:688163

Mimica, Ninoslav, et al. "Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features." Collegium Antropologicum, vol. 32, no. S. 1, 2008, pp. 119-122. https://urn.nsk.hr/urn:nbn:hr:105:688163

Mimica, Ninoslav, Dorotea Mück Šeler, Nela Pivac, Maja Mustapić, Martina Deželjin, Tamara Stipčević, Paola Presečki, Elizabeta Radonić and Vera Folnegović Šmalc. "Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features." Collegium Antropologicum 32, no. S. 1 (2008): 119-122. https://urn.nsk.hr/urn:nbn:hr:105:688163

Mimica, N., et al. (2008) 'Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features', Collegium Antropologicum, 32(S. 1), pp. 119-122. Available at: https://urn.nsk.hr/urn:nbn:hr:105:688163 (Accessed 02 December 2024)

Mimica N, Mück Šeler D, Pivac N, Mustapić M, Deželjin M, Stipčević T, and sur.. Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features. Collegium Antropologicum [Internet]. 2008 January [cited 2024 December 02];32(S. 1):119-122. Available at: https://urn.nsk.hr/urn:nbn:hr:105:688163

N. Mimica, et al., "Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features", Collegium Antropologicum, vol. 32, no. S. 1, pp. 119-122, January 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:688163. [Accessed: 02 December 2024]

Metadata
Title (english)Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features
AuthorNinoslav Mimica
AuthorDorotea Mück-Šeler
AuthorNela Pivac
AuthorMaja Mustapić
AuthorMartina Deželjin
AuthorTamara Stipčević
AuthorPaola Presečki
AuthorElizabeta Radonić
AuthorVera Folnegović-Šmalc
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Post mortem brain studies indicate that alterations in serotonergic and catecholaminergic systems might be associated with Alzheimer's disease (AD). The aim of the study was to determine serotonin (5-HT) levels and monoamine oxidase type B (MAO-B) activity in platelets of psychotic and non-psychotic patients with AD, established according to the NINCDS-ADRDA and DSM-IV-TR criteria. Cognitive impairment and psychotic features were evaluated using Mini Mental Status Examination and Neuropsychiatric Inventory. Platelet 5-HT concentration and MAO-B activity were determined spectrofluorimetrically in 116 (51 male, 65 female) healthy subjects and 70 psychotic (10 male, 60 female) and 151 non-psychotic (32 male, 119 female) patients. Psychotic and non-psychotic female and psychotic male patients had significantly lower platelet 5-HT concentration than corresponding sex matched control subjects. Platelet MAO-B activity was significantly increased in both male and female non-psychotic patients compared to the sex matched controls. Non-psychotic female patients had significantly higher platelet MAO-B activity than psychotic female patients. Our data suggest that platelet MAO-B activity, but not platelet 5-HT concentration, could differentiate between psychotic and non-psychotic subtypes of AD.
Abstract (croatian)
Post mortem istraživanja su pokazala promjene serotoninskog i kateholaminskog sustava u mozgu oboljelih od Alzheimerove bolesti (AB). Cilj istraživanja bio je odrediti koncentraciju trombocitnog serotonina (5-HT) i aktivnost trombocitne monoaminooksidaze tipa B (MAO-B) u bolesnika s AB sa ili bez psihotičnih simptoma i u skupini zdravih osoba. Dijagnoza vjerojatne AB (NINCDS-ADRDA kriterij) postavljena je u skladu s DSM-IV kriterijima. Za procjenu kognitivnog oštećenja korištena je Mini Mental Status Examination, a za određivanje psihotičnih simptoma Neuropsychiatric Inventory. U trombocitima 116 zdravih osoba (51 muškarac, 65 žena), 70 bolesnika (10 muškaraca, 60 žena) sa psihotičkim simptomima i 151 bolesnika (32 muškarca, 119 žena) bez psihotičkih simptoma određena je koncentracija 5-HT i aktivnost MAO-B pomoću spektrofluorimetrijskih metoda. Koncentracija trombocitnog 5-HT bila je značajno snižena u bolesnica sa psihotičkim i nepsihotičkim simptomima te u nepsihotičkih bolesnika u odnosu na koncentraciju trombocitnog 5-HT u odgovarajućoj skupini zdravih žena i muškaraca. Aktivnost trombocitne MAO-B bila je povećana u muških i ženskih nepsihotičkih bolesnika s AB u usporedbi s aktivnošću u zdravoj kontroli odgovarajućeg spola. U trombocitima nepsihotičkih ženskih bolesnica pronađena je značajno povećana aktivnost MAO-B u odnosu na aktivnost enzima u trombocitima bolesnica sa psihotičkim simptomima. Rezultati istraživanja upućuju da bi aktivnost trombocitne MAO-B mogla biti biokemijski pokazatelj za razlikovanje psihotičkog i nepsihotičkog oblika AB.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. S. 1, pp. 119-122
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:688163
Publication2008-01
Document URLhttps://hrcak.srce.hr/24564
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:47:49